Hide metadata

dc.date.accessioned2020-02-05T19:05:57Z
dc.date.available2020-02-05T19:05:57Z
dc.date.created2018-11-14T12:57:05Z
dc.date.issued2018
dc.identifier.citationHallmer, Fredrik Anderson, Gunilla Gotrick, Bengt Warfvinge, Gunnar Anderud, Jonas Bjørnland, Tore . Prevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw?a 4-year prospective study. Oral surgery, oral medicine, oral pathology and oral radiology. 2018, 1-9
dc.identifier.urihttp://hdl.handle.net/10852/72783
dc.description.abstractObjectives Medication-related osteonecrosis of the jaw (MRONJ) has a wide range of prevalence, and a standard therapy has not yet been established. The aim of this study was to analyze the prevalence and initiating factors of MRONJ and the outcomes of surgical therapy. Study Design In a prospective cohort study, all patients diagnosed with MRONJ in the Region of Skåne, in Sweden, were included. Predictor variables (comorbidity, site, stage, gender) and initiating factors (tooth extraction, periodontitis) were recorded. Surgical treatment was sequestrectomy or block resection, and the outcome variable was healing after 2 months. To estimate the prevalence, data on the use of bisphosphonate and denosumab were used. Results Fifty-five patients with MRONJ were identified. The prevalence of MRONJ was 0.043% among patients treated with oral bisphosphonates, 1.03% among those on intravenous bisphosphonates and 3.64% in those on high-dose denosumab. Periodontal disease preceded development of MRONJ in 41 patients. Fifty patients were treated surgically and followed up for at least 2 months. Remission or healing occurred in 80% of patients treated with sequestrectomy and in 92.5% of patients treated with block resection. Conclusions The prevalence of MRONJ in Sweden is low. Periodontitis is the most common initiating factor. The outcome of treatment of MRONJ is healing in most patients treated surgically.
dc.languageEN
dc.titlePrevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw?a 4-year prospective study
dc.typeJournal article
dc.creator.authorHallmer, Fredrik
dc.creator.authorAnderson, Gunilla
dc.creator.authorGotrick, Bengt
dc.creator.authorWarfvinge, Gunnar
dc.creator.authorAnderud, Jonas
dc.creator.authorBjørnland, Tore
cristin.unitcode185,16,17,51
cristin.unitnameOral kirurgi og oral medisin
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1
dc.identifier.cristin1630459
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Oral surgery, oral medicine, oral pathology and oral radiology&rft.volume=&rft.spage=1&rft.date=2018
dc.identifier.jtitleOral surgery, oral medicine, oral pathology and oral radiology
dc.identifier.volume126
dc.identifier.issue6
dc.identifier.startpage477
dc.identifier.endpage485
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2018.08.015
dc.identifier.urnURN:NBN:no-75912
dc.type.documentTidsskriftartikkel
dc.source.issn2212-4403
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/72783/1/Bj%25C3%25B8rnlandFulltekst.pdf
dc.type.versionSubmittedVersion


Files in this item

Appears in the following Collection

Hide metadata