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dc.date.accessioned2020-01-22T15:12:41Z
dc.date.available2020-01-22T15:12:41Z
dc.date.created2018-10-06T12:26:23Z
dc.date.issued2018
dc.identifier.citationHøglund, Rune Alexander Polak, Justyna Vartdal, Frode Holmøy, Trygve Lossius, Andreas Lunde . B-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarate. Multiple Sclerosis and Related Disorders. 2018, 26, 90-95
dc.identifier.urihttp://hdl.handle.net/10852/72435
dc.description.abstractBackground B cells may contribute to the immunopathogenesis of multiple sclerosis (MS). Dimethyl fumarate (DMF) has recently been shown to reduce the frequency of memory B cells in blood, but it is not known whether the drug influences the cellular composition in the cerebrospinal fluid (CSF). Methods A cross-sectional study examining the cellular composition in blood and cerebrospinal fluid (CSF) from 10 patients treated with DMF and 18 patients receiving other disease modifying drugs or no treatment. Results Patients treated with DMF had reduced proportions of memory B cells in blood compared to other MS patients (p = 0.0007), and the reduction correlated with treatment duration (rs = −0.75, p = 0.021). In the CSF, the absolute number of mononuclear cells were significantly lower in DMF-treated patients compared to the other patients (p = 0.023), and there was a disproportionate decrease of plasmablasts (p = 0.031). Conclusion The results of this exploratory study support a B-cell mediated mechanism of action for DMF in both blood and CSF.en_US
dc.languageEN
dc.language.isoenen_US
dc.relation.ispartofHøglund, R.A. (2020) B cells in Multiple Sclerosis - on idiotopes and antigen presentation. Doctoral thesis http://hdl.handle.net/10852/80722
dc.relation.urihttp://hdl.handle.net/10852/80722
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleB-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarateen_US
dc.typeJournal articleen_US
dc.creator.authorHøglund, Rune Alexander
dc.creator.authorPolak, Justyna
dc.creator.authorVartdal, Frode
dc.creator.authorHolmøy, Trygve
dc.creator.authorLossius, Andreas Lunde
cristin.unitcode185,53,42,0
cristin.unitnameNevroklinikken
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1618354
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Multiple Sclerosis and Related Disorders&rft.volume=26&rft.spage=90&rft.date=2018
dc.identifier.jtitleMultiple Sclerosis and Related Disorders
dc.identifier.volume26
dc.identifier.startpage90
dc.identifier.endpage95
dc.identifier.doihttps://doi.org/10.1016/j.msard.2018.08.032
dc.identifier.urnURN:NBN:no-75521
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2211-0348
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/72435/1/B-cell%2Bcomposition%2Bin%2Bthe%2Bblood%2Band%2Bcerebrospinal%2Bfluid.pdf
dc.type.versionAcceptedVersion


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