• English
    • Norsk
  • English 
    • English
    • Norsk
  • Administration
View Item 
  •   Home
  • Øvrige samlinger
  • Høstingsarkiver
  • CRIStin høstingsarkiv
  • View Item
  •   Home
  • Øvrige samlinger
  • Høstingsarkiver
  • CRIStin høstingsarkiv
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Testing Genetic and Environmental Associations Between Personality Disorders and Cocaine Use: A Population-Based Twin Study

Gillespie, Nathan A.; Aggen, Steven H.; Gentry, Amanda E.; Neale, Michael Churton; Knudsen, Gun Peggy S.; Krueger, Robert Frederick; South, Susan Carol; Czajkowski, Nikolai Olavi; Nesvåg, Ragnar; Ystrøm, Eivind; Rosenström, Tom Henrik; Torvik, Fartein Ask; Reichborn-Kjennerud, Ted; Kendler, Kenneth Seedman
Journal article; PublishedVersion; Peer reviewed
View/Open
Testing+Genetic ... ation-Based+Twin+Study.pdf (235.1Kb)
Year
2018
Permanent link
http://urn.nb.no/URN:NBN:no-75034

CRIStin
1595265

Metadata
Show metadata
Appears in the following Collection
  • Institutt for klinisk medisin [5809]
  • Psykologisk institutt [2978]
  • Farmasøytisk institutt [1379]
  • CRIStin høstingsarkiv [16801]
Original version
Twin Research and Human Genetics. 2018, 21 (1), 24-32, DOI: https://doi.org/10.1017/thg.2017.73
Abstract
Until now, data have not been available to elucidate the genetic and environmental sources of comorbidity between all 10 DSM-IV personality disorders (PDs) and cocaine use. Our aim was to determine which PD traits are linked phenotypically and genetically to cocaine use. Cross-sectional data were obtained in a face-to-face interview between 1999 and 2004. Subjects were 1,419 twins (µage = 28.2 years, range = 19–36) from the Norwegian Institute of Public Health Twin Panel, with complete lifetime cocaine use and criteria for all 10 DSM-IV PDs. Stepwise multiple and Least Absolute Shrinkage and Selection Operator (LASSO) regressions were used to identify PDs related to cocaine use. Twin models were fitted to estimate genetic and environmental associations between the PD traits and cocaine use. In the multiple regression, antisocial (OR = 4.24, 95% CI [2.66, 6.86]) and borderline (OR = 2.19, 95% CI [1.35, 3.57]) PD traits were significant predictors of cocaine use. In the LASSO regression, antisocial, borderline, and histrionic were significant predictors of cocaine use. Antisocial and borderline PD traits each explained 72% and 25% of the total genetic risks in cocaine use, respectively. Genetic risks in histrionic PD were not significantly related to cocaine use. Importantly, after removing criteria referencing substance use, antisocial PD explained 65% of the total genetic variance in cocaine use, whereas borderline explained only 4%. Among PD traits, antisocial is the strongest correlate of cocaine use, for which the association is driven largely by common genetic risks.
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy
 

 

For students / employeesSubmit master thesisAccess to restricted material

Browse

All of DUOCommunities & CollectionsBy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

For library staff

Login
RSS Feeds
 
Responsible for this website 
University of Oslo Library


Contact Us 
duo-hjelp@ub.uio.no


Privacy policy