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dc.date.accessioned2019-12-18T20:10:21Z
dc.date.available2019-12-18T20:10:21Z
dc.date.created2018-08-01T11:38:48Z
dc.date.issued2018
dc.identifier.citationKrogsrud, Stine Kleppe Fjell, Anders Martin Tamnes, Christian Krog Grydeland, Håkon Due-Tønnessen, Paulina Bjørnerud, Atle Sampaio-Baptista, Cassandra Andersson, Jesper Johansen-Berg, Heidi Walhovd, Kristine B . Development of white matter microstructure in relation to verbal and visuospatial working memory - A longitudinal study. PLoS ONE. 2018, 13:e0195540(4), 1-22
dc.identifier.urihttp://hdl.handle.net/10852/71718
dc.description.abstractWorking memory capacity is pivotal for a broad specter of cognitive tasks and develops throughout childhood. This must in part rely on development of neural connections and white matter microstructure maturation, but there is scarce knowledge of specific relations between this and different aspects of working memory. Diffusion tensor imaging (DTI) enables us to study development of brain white matter microstructure. In a longitudinal DTI study of 148 healthy children between 4 and 11 years scanned twice with an on average 1.6 years interval, we characterized change in fractional anisotropy (FA), mean (MD), radial (RD) and axial diffusivity (AD) in 10 major white matter tracts hypothesized to be of importance for working memory. The results showed relationships between change in several tracts and change in visuospatial working memory. Specifically, improvement in visuospatial working memory capacity was significantly associated with decreased MD, RD and AD in inferior longitudinal fasciculus (ILF), inferior fronto-occipital fasciculus (IFOF) and uncinate fasciculus (UF) in the right hemisphere, as well as forceps major (FMaj). No significant relationships were found between change in DTI metrics and change in verbal working memory capacity. These findings yield new knowledge about brain development and corresponding working memory improvements in childhood.en_US
dc.languageEN
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDevelopment of white matter microstructure in relation to verbal and visuospatial working memory - A longitudinal studyen_US
dc.typeJournal articleen_US
dc.creator.authorKrogsrud, Stine Kleppe
dc.creator.authorFjell, Anders Martin
dc.creator.authorTamnes, Christian Krog
dc.creator.authorGrydeland, Håkon
dc.creator.authorDue-Tønnessen, Paulina
dc.creator.authorBjørnerud, Atle
dc.creator.authorSampaio-Baptista, Cassandra
dc.creator.authorAndersson, Jesper
dc.creator.authorJohansen-Berg, Heidi
dc.creator.authorWalhovd, Kristine B
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1599323
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=13:e0195540&rft.spage=1&rft.date=2018
dc.identifier.jtitlePLoS ONE
dc.identifier.volume13:e0195540
dc.identifier.issue4
dc.identifier.startpage1
dc.identifier.endpage22
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0195540
dc.identifier.urnURN:NBN:no-74845
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/71718/2/https___journals.plos.org_plosone_article_file_id%253D10.1371_journal.pone.pdf
dc.type.versionPublishedVersion


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