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dc.date.accessioned2019-12-08T19:10:33Z
dc.date.available2019-12-08T19:10:33Z
dc.date.created2018-07-16T15:34:10Z
dc.date.issued2018
dc.identifier.citationEide, Per Kristian Vatnehol, Svein Are Sirirud Emblem, Kyrre Eeg Ringstad, Geir . Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes. Scientific Reports. 2018, 8(1), 1-10
dc.identifier.urihttp://hdl.handle.net/10852/71390
dc.description.abstractPre-clinical research in rodents provides evidence that the central nervous system (CNS) has functional lymphatic vessels. In-vivo observations in humans, however, are not demonstrated. We here show data on CNS lymphatic drainage to cervical lymph nodes in-vivo by magnetic resonance imaging (MRI) enhanced with an intrathecal contrast agent as a cerebrospinal fluid (CSF) tracer. Standardized MRI of the intracranial compartment and the neck were acquired before and up to 24–48 hours following intrathecal contrast agent administration in 19 individuals. Contrast enhancement was radiologically confirmed by signal changes in CSF nearby inferior frontal gyrus, brain parenchyma of inferior frontal gyrus, parahippocampal gyrus, thalamus and pons, and parenchyma of cervical lymph node, and with sagittal sinus and neck muscle serving as reference tissue for cranial and neck MRI acquisitions, respectively. Time series of changes in signal intensity shows that contrast enhancement within CSF precedes glymphatic enhancement and peaks at 4–6 hours following intrathecal injection. Cervical lymph node enhancement coincides in time with peak glymphatic enhancement, with peak after 24 hours. Our findings provide in-vivo evidence of CSF tracer drainage to cervical lymph nodes in humans. The time course of lymph node enhancement coincided with brain glymphatic enhancement rather than with CSF enhancement.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMagnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes
dc.typeJournal article
dc.creator.authorEide, Per Kristian
dc.creator.authorVatnehol, Svein Are Sirirud
dc.creator.authorEmblem, Kyrre Eeg
dc.creator.authorRingstad, Geir
cristin.unitcode185,53,42,11
cristin.unitnameNevrokirurgisk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1597519
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=8&rft.spage=1&rft.date=2018
dc.identifier.jtitleScientific Reports
dc.identifier.volume8
dc.identifier.issue1
dc.identifier.doihttps://doi.org/10.1038/s41598-018-25666-4
dc.identifier.urnURN:NBN:no-74532
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/71390/1/Eide%2Bet%2Bal.pdf
dc.type.versionPublishedVersion
cristin.articleid7194


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