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dc.date.accessioned2019-11-25T19:46:17Z
dc.date.available2019-11-25T19:46:17Z
dc.date.created2018-08-12T14:37:45Z
dc.date.issued2018
dc.identifier.citationRogne, Marie Svärd, Oksana Madsen-Østerbye, Julia-Kristina Jensen Hashim, Adnan Tjønnfjord, Geir Erland Staerk, Judith . Cytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia. Journal of Cellular and Molecular Medicine. 2018, 22(5), 2846-2855
dc.identifier.urihttp://hdl.handle.net/10852/71012
dc.description.abstractCytokinesis failure leads to the emergence of tetraploid cells and multiple centrosomes. Chronic lymphocytic leukaemia (CLL) is the most common haematological malignancy in adults and is characterized by clonal B cell expansion. Here, we show that a significant number of peripheral blood CLL cells are arrested in cytokinesis and that this event occurred after nuclear envelope reformation and before cytoplasmic abscission. mRNA expression data showed that several genes known to be crucial for cell cycle regulation, checkpoint and centromere function, such as ING4, ING5, CDKN1A and CDK4, were significantly dysregulated in CLL samples. Our results demonstrate that CLL cells exhibit difficulties in completing mitosis, which is different from but may, at least in part, explain the previously reported accumulation of CLL cells in G0/1.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleCytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia
dc.title.alternativeENEngelskEnglishCytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia
dc.typeJournal article
dc.creator.authorRogne, Marie
dc.creator.authorSvärd, Oksana
dc.creator.authorMadsen-Østerbye, Julia-Kristina Jensen
dc.creator.authorHashim, Adnan
dc.creator.authorTjønnfjord, Geir Erland
dc.creator.authorStaerk, Judith
cristin.unitcode185,57,0,0
cristin.unitnameNorsk Senter for Molekylærmedisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1601285
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Cellular and Molecular Medicine&rft.volume=22&rft.spage=2846&rft.date=2018
dc.identifier.jtitleJournal of Cellular and Molecular Medicine
dc.identifier.volume22
dc.identifier.issue5
dc.identifier.startpage2846
dc.identifier.endpage2855
dc.identifier.doihttps://doi.org/10.1111/jcmm.13579
dc.identifier.urnURN:NBN:no-74105
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1582-1838
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/71012/2/Cytokinesis%2Barrest%2Band%2Bmultiple%2Bcentrosomes%2Bin%2BB%2Bcell%2Bchronic%2Blymphocytic%2Bleukaemia.pdf
dc.type.versionPublishedVersion


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