Today there are no clear guidelines on how beta-blockers should be used to treat patients with myocardial infarction without heart failure (defined as EF > 40%). The research supporting the use of beta-blockers to treat myocardial infarction is from the 1980s. However, in the last 40 years the patient population has changed, and new medication and technology have been implemented. This paper is a literature study which will address the following question: Does a scientific basis exist to treat the present-day myocardial infarction patients without heart failure with beta-blockers? The paper is divided into two parts; the first part will look into the literature supporting the use of beta-blockers to treat myocardial infarction with heart failure, while the second part will look into the literature investigating the use of beta-blockers for myocardial infarction without heart failure. The results of this paper show that today there are no published research which give a clear conclusion on whether beta-blockers are useful to treat myocardial infarction without heart failure or not. Furthermore, the results show that the medical development and the patient population in the 1980s differs from today’s situation to such extent that the results from the studies done 40 years ago cannot be applied to today’s patients. Hopefully results from the ongoing studies in Norway and Sweden who look into the use of beta-blockers as treatment for myocardial infarction in patients without heart failure will give a clear conclusion on whether beta-blockers are useful or not for this patient group.