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dc.date.accessioned2019-09-12T05:27:56Z
dc.date.available2019-09-12T05:27:56Z
dc.date.created2019-07-30T13:18:46Z
dc.date.issued2019
dc.identifier.citationHvidsten, Lara H. Thomasgaard Engedal, Knut Selbæk, Geir Wyller, Torgeir Bruun Saltyte Benth, Jurate Kersten, Hege . Quality of Life of Family Carers of Persons with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter. PLOS ONE. 2019, 14(7)
dc.identifier.urihttp://hdl.handle.net/10852/70352
dc.description.abstractObjectives To identify factors associated with QOL in carers of persons with young-onset Alzheimer’s (AD) and frontotemporal dementia (FTD) and explore development in QOL over a two-year period. Methods Eighty-eight family carers of community-dwelling people with young-onset AD (n = 50) and FTD (n = 38) recruited from Nordic memory clinics. Carer QOL was assessed using the Quality of Life–Alzheimer’s Disease questionnaire. Carer burden was assessed by the Relatives’ Stress scale and depressive symptoms by the Montgomery-Åsberg Depression Rating Scale. Factors associated with QOL in YOD and development in QOL over time were explored with growth mixture model trajectories and mixed model analyses. Results We identified two carer groups of persons with YOD following trajectories with better (n = 53) versus poorer (n = 30) QOL. Carers who reported more burden at baseline had greater odds of belonging to the poorer QOL group (OR 1.1 (1.0–1.2), p = 0.004). Analyses of the development in QOL showed a significant decline in QOL–AD scores among the AD-carers from baseline to two-year follow-up (p = 0.044), while the score remained stable among the FTD-carers. The FTD-carer group had significantly higher mean QOL–AD scores at one- and two-year follow-up (p = 0.022 and 0.045, respectively). However, the difference between the two groups regarding time trend was non-significant. Poorer QOL was associated with increased carer burden (p = 0.01), more depressive symptoms (p = 0.024), and being male carer (p = 0.038). Conclusion Higher care burden, more depressive symptoms, and being a male carer was associated with poorer QOL in family carers for persons with YOD. Carers of persons with AD may experience greater challenges in preserving QOL compared to carers of persons with FTD.
dc.languageEN
dc.publisherPLOS
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleQuality of Life of Family Carers of Persons with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter
dc.typeJournal article
dc.creator.authorHvidsten, Lara H. Thomasgaard
dc.creator.authorEngedal, Knut
dc.creator.authorSelbæk, Geir
dc.creator.authorWyller, Torgeir Bruun
dc.creator.authorSaltyte Benth, Jurate
dc.creator.authorKersten, Hege
cristin.unitcode185,53,11,15
cristin.unitnameGeriatrisk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1713211
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLOS ONE&rft.volume=14&rft.spage=&rft.date=2019
dc.identifier.jtitlePLOS ONE
dc.identifier.volume14
dc.identifier.issue7
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0219859
dc.identifier.urnURN:NBN:no-73486
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/70352/2/Hvidsten%2Bet%2Bal.pdf
dc.type.versionPublishedVersion
cristin.articleide0219859


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