Author: Frida Karine Feyer Title: How I See Myself in You. Social Perception and Clinical Insight in Schizophrenia Supervisors: Professor Stein Andersson and Senior Research Psychologist Anja Vaskinn Background: Schizophrenia is a severe mental disorder that leads to big functional impairments and debilitating symptoms in patients and that can be hard to treat sufficiently. One obstacle to sufficient treatment of schizophrenia, is lack of clinical insight as it is associated with poor treatment adherence and poor functioning. Clinical insight has been researched in relation to several aspects of schizophrenia, but the cause of insight deficits is still largely unclear. Research has, however, indicated that social cognition and/or psychotic symptoms may be central to insight deficits. The aim of this study, was to investigate clinical insight in relation to one less-researched domain of social cognition, social perception, as well as to schizophrenia symptoms. In addition, the study was to control for effects of non-social cognition as several studies have reported associations between social cognition and non-social cognition. Methods: The participants were 55 patients with schizophrenia or schizoaffective disorder, all recruited from the Social Cognition Training in Schizophrenia study at NORMENT Centre for Psychosis Research. The student participated in data collection, and the dataset was extracted from the NORMENT database. Clinical Insight was measured with the Birchwood Self-report Insight Scale for Psychosis, Relationships across Domains was used to measure Social Perception, symptom level was measured with the Positive and Negative Syndrome Scale (PANSS) and non-social cognition was measured with the MATRICS Consensus Cognitive battery (MCCB). Results were analyzed using bivariate correlation analysis and hierarchical regression analysis. Results: Bivariate correlation analyses showed moderate correlations between social perception and awareness of illness, between positive symptoms and total insight, and between disorganized symptoms and all domains except need for treatment. Non-social cognition correlated with total insight and awareness of illness. Hierarchical regression analyses showed that social perception predicted awareness of illness, while disorganized symptoms predicted total insight and relabeling of symptoms. None of the other variables individually contributed to clinical insight. The study VI found a relationship between non-social cognition, social cognition, symptoms and clinical insight where different domains of insight had different predictors, and social perception and disorganized symptoms contributed uniquely to clinical insight. Implications of the study are that social cognition contributes to clinical insight together with symptoms, and that non-social cognition may contribute to clinical insight, but only indirectly through executive function that is also seem to be measured through disorganized symptoms. More research is needed in order to fully understand the relationship between social and non-social cognition and symptoms in relation to clinical insight.