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dc.date.accessioned2019-06-24T05:29:53Z
dc.date.available2019-06-24T05:29:53Z
dc.date.created2019-04-30T13:25:25Z
dc.date.issued2019
dc.identifier.citationKahrs, Christian Riddervold Chuda, Katerina Tapia, German Stene, Lars Christian Mørch Mårild, Karl Staffan Rasmussen, Trond Rønningen, Kjersti Skjold Lundin, Knut Erik Aslaksen Kramna, Lenka Cinek, Ondrej Størdal, Ketil . Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort. BMJ (Clinical Research Edition). 2019, 364(l231)
dc.identifier.urihttp://hdl.handle.net/10852/68478
dc.description.abstractObjective To determine whether infection with human enterovirus or adenovirus, both common intestinal viruses, predicts development of coeliac disease. Design Case-control study nested within Norwegian birth cohort recruited between 2001 and 2007 and followed to September 2016. Setting Norwegian population. Participants Children carrying the HLA genotype DR4-DQ8/DR3-DQ2 conferring increased risk of coeliac disease. Exposures Enterovirus and adenovirus detected using real time polymerase chain reaction in monthly stool samples from age 3 to 36 months. Main outcome measure Coeliac disease diagnosed according to standard criteria. Coeliac disease antibodies were tested in blood samples taken at age 3, 6, 9, and 12 months and then annually. Adjusted odds ratios from mixed effects logistic regression model were used to assess the relation between viral infections before development of coeliac disease antibodies and coeliac disease. Results Among 220 children, and after a mean of 9.9 (SD 1.6) years, 25 children were diagnosed as having coeliac disease after screening and were matched to two controls each. Enterovirus was found in 370 (17%) of 2135 samples and was significantly more frequent in samples collected before development of coeliac disease antibodies in cases than in controls (adjusted odds ratio 1.49, 95% confidence interval 1.07 to 2.06; P=0.02). The association was restricted to infections after introduction of gluten. High quantity samples (>100 000 copies/μL) (adjusted odds ratio 2.11, 1.24 to 3.60; P=0.01) and long lasting infections (>2 months) (2.16, 1.16 to 4.04; P=0.02) gave higher risk estimates. Both the commonly detected enterovirus species Enterovirus A and Enterovirus B were significantly associated with coeliac disease. The association was not found for infections during or after development of coeliac disease antibodies. Adenovirus was not associated with coeliac disease. Conclusions In this longitudinal study, a higher frequency of enterovirus, but not adenovirus, during early childhood was associated with later coeliac disease. The finding adds new information on the role of viral infections in the aetiology of coeliac disease.
dc.languageEN
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleEnterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort
dc.typeJournal article
dc.creator.authorKahrs, Christian Riddervold
dc.creator.authorChuda, Katerina
dc.creator.authorTapia, German
dc.creator.authorStene, Lars Christian Mørch
dc.creator.authorMårild, Karl Staffan
dc.creator.authorRasmussen, Trond
dc.creator.authorRønningen, Kjersti Skjold
dc.creator.authorLundin, Knut Erik Aslaksen
dc.creator.authorKramna, Lenka
dc.creator.authorCinek, Ondrej
dc.creator.authorStørdal, Ketil
cristin.unitcode185,53,0,0
cristin.unitnameInstitutt for klinisk medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1694761
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ (Clinical Research Edition)&rft.volume=364&rft.spage=&rft.date=2019
dc.identifier.jtitleBMJ (Clinical Research Edition)
dc.identifier.pagecount8
dc.identifier.doihttp://dx.doi.org/10.1136/bmj.l231
dc.identifier.urnURN:NBN:no-71632
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn0959-8138
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/68478/1/Kahrs_2019_Ent.pdf
dc.type.versionPublishedVersion
cristin.articleid364


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