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dc.date.accessioned2019-05-08T14:45:33Z
dc.date.available2019-05-16T22:47:08Z
dc.date.created2019-01-24T11:09:40Z
dc.date.issued2018
dc.identifier.citationMcCarthy, Michael J. Stautland, Andrea Jakobsen, Petter Ødegaard, Ketil Joachim Andreassen, Ole Andreas Djurovic, Srdjan Morken, Gunnar Schøyen, Helle Kristine McInnis, Melvin G. Alda, Martin Gage, Fred H. Calabrese, Joseph R. Zandi, Peter P. Nievergelt, Caroline M. Shilling, Paul D. Kelsoe, John R. . Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology. 2018
dc.identifier.urihttp://hdl.handle.net/10852/67923
dc.description.abstractBipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs. evening preference (chronotype) as a dimension of circadian rhythm function in 193 Li-R and Li-NR BD patients. From a subset of 59 patients, we measured circadian rhythms in fibroblasts longitudinally over 5 days using a bioluminescent reporter (Per2-luc). We then estimated circadian rhythm parameters (amplitude, period, phase) and the pharmacological effects of lithium on rhythms in cells from Li-R and Li-NR donors. Compared to Li-NRs, Li-Rs showed a difference in chronotype, with higher levels of morningness. Evening chronotype was associated with increased mood symptoms at baseline, including depression, mania, and insomnia. Cells from Li-R patients were more likely to exhibit a short circadian period, a linear relationship between period and phase, and period shortening effects of lithium. Common genetic variation in the IP3 signaling pathway may account for some of the individual differences in the effects of lithium on cellular rhythms. We conclude that circadian rhythms may influence response to lithium in maintenance treatment of BD.en_US
dc.languageEN
dc.publisherElsevier Science
dc.titleChronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorderen_US
dc.typeJournal articleen_US
dc.creator.authorMcCarthy, Michael J.
dc.creator.authorStautland, Andrea
dc.creator.authorJakobsen, Petter
dc.creator.authorØdegaard, Ketil Joachim
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorDjurovic, Srdjan
dc.creator.authorMorken, Gunnar
dc.creator.authorSchøyen, Helle Kristine
dc.creator.authorMcInnis, Melvin G.
dc.creator.authorAlda, Martin
dc.creator.authorGage, Fred H.
dc.creator.authorCalabrese, Joseph R.
dc.creator.authorZandi, Peter P.
dc.creator.authorNievergelt, Caroline M.
dc.creator.authorShilling, Paul D.
dc.creator.authorKelsoe, John R.
cristin.unitcode185,53,10,70
cristin.unitnameNORMENT part UiO
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1664274
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuropsychopharmacology&rft.volume=&rft.spage=&rft.date=2018
dc.identifier.jtitleNeuropsychopharmacology
dc.identifier.doihttp://dx.doi.org/10.1038/s41386-018-0273-8
dc.identifier.urnURN:NBN:no-71089
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0893-133X
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/67923/2/Chronotype%2Band%2Bcellular%2Bcircadian%2Brhythms.pdf
dc.type.versionAcceptedVersion


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