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dc.date.accessioned2019-02-18T11:19:46Z
dc.date.created2018-05-17T15:24:00Z
dc.date.issued2018
dc.identifier.citationNilsen, Jeannette Sandlie, Inger Roopenian, Derry C. Andersen, Jan Terje . Animal models for evaluation of albumin-based therapeutics. Current Opinion in Chemical Engineering. 2018, 19, 68-76
dc.identifier.urihttp://hdl.handle.net/10852/66589
dc.description.abstractAlbumin has a long serum half-life due to its unique ability to bind the cellular neonatal Fc receptor (FcRn), which provides protection from intracellular degradation. The interaction can be capitalized to improve the efficacy of drugs by extending their serum persistence. However, species-specific binding of albumin to FcRn challenges preclinical development. The goal of this brief review is to provide insights into how FcRn and cross-species binding differences affect the pharmacokinetics of human serum albumin (HSA) in different animal models, and gives an overview of genetically modified mice that may serve as improved models for testing of albumin-based drugs.en_US
dc.languageEN
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleAnimal models for evaluation of albumin-based therapeuticsen_US
dc.typeJournal articleen_US
dc.creator.authorNilsen, Jeannette
dc.creator.authorSandlie, Inger
dc.creator.authorRoopenian, Derry C.
dc.creator.authorAndersen, Jan Terje
dc.date.embargoenddate2020-01-10
cristin.unitcode185,53,18,12
cristin.unitnameAvdeling for immunologi og transfusjonsmedisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1585513
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current Opinion in Chemical Engineering&rft.volume=19&rft.spage=68&rft.date=2018
dc.identifier.jtitleCurrent Opinion in Chemical Engineering
dc.identifier.volume19
dc.identifier.startpage68
dc.identifier.endpage76
dc.identifier.doihttp://dx.doi.org/10.1016/j.coche.2017.11.007
dc.identifier.urnURN:NBN:no-69777
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2211-3398
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/66589/2/Revised_Animal%252Bmodels%252Bfor%252Bevaluation%252Bof%252Balbumin-based%252Btherapeutics.pdf
dc.type.versionAcceptedVersion
dc.relation.projectNFR/230526
dc.relation.projectNFR/179573


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Attribution-NonCommercial-NoDerivatives 4.0 International
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