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dc.date.accessioned2019-02-07T13:21:10Z
dc.date.available2019-02-07T13:21:10Z
dc.date.created2018-11-07T12:35:43Z
dc.date.issued2018
dc.identifier.citationHansen, Charlotte Holst Ritschel, Vibeke Nordmo Andersen, Geir Øystein Halvorsen, Sigrun Eritsland, Jan Arnesen, Harald Seljeflot, Ingebjørg . Markers of thrombin generation are associated with long-term clinical outcome in patients With ST-segment elevation myocardial infarction. Clinical and applied thrombosis/hemostasis. 2018, 24(7), 1088-1094
dc.identifier.urihttp://hdl.handle.net/10852/66427
dc.description.abstractHypercoagulability in ST-segment elevation myocardial infarction (STEMI) as related to long-term clinical outcome is not clarified. We aimed to investigate whether prothrombin fragment 1+2 (F1+2), d-dimer, and endogenous thrombin potential (ETP) measured in the acute phase of STEMI were associated with outcome. Blood samples were drawn median 24 hours after symptom onset in 987 patients with STEMI. Median follow-up time was 4.6 years. Primary outcome was a composite of all-cause mortality, reinfarction, stroke, unscheduled revascularization, or rehospitalization for heart failure; secondary outcome was total mortality. The number of combined end points/total mortality was 195/79. Higher levels of d-dimer and F1+2 were observed with both end points (all P < .005), whereas ETP was significantly lower (P < .01). Dichotomized at medians, increased risk was observed for levels above median for F1+2 and d-dimer (combined end point P = .020 and P = .010 and total mortality P < .001, both), while an inverse pattern was observed for ETP (P < .02, both). Adjusting for covariates, d-dimer was still associated with reduced risk of total mortality (P = .034) and receiver operating characteristic curve analyses showed area under the curve of 0.700 (95% confidence interval, 0.640-0.758). The hypercoagulable state in acute STEMI seems to be of importance for clinical outcome.en_US
dc.languageEN
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleMarkers of thrombin generation are associated with long-term clinical outcome in patients With ST-segment elevation myocardial infarctionen_US
dc.typeJournal articleen_US
dc.creator.authorHansen, Charlotte Holst
dc.creator.authorRitschel, Vibeke Nordmo
dc.creator.authorAndersen, Geir Øystein
dc.creator.authorHalvorsen, Sigrun
dc.creator.authorEritsland, Jan
dc.creator.authorArnesen, Harald
dc.creator.authorSeljeflot, Ingebjørg
cristin.unitcode185,53,11,10
cristin.unitnameHjertemedisinsk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1627909
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical and applied thrombosis/hemostasis&rft.volume=24&rft.spage=1088&rft.date=2018
dc.identifier.jtitleClinical and applied thrombosis/hemostasis
dc.identifier.volume24
dc.identifier.issue7
dc.identifier.startpage1088
dc.identifier.endpage1094
dc.identifier.doihttp://dx.doi.org/10.1177/1076029618764847
dc.identifier.urnURN:NBN:no-69630
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1076-0296
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/66427/1/Hansen%2Bet%2Bal.pdf
dc.type.versionPublishedVersion


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