Diabetes, preeclampsia and infant death: The associations with placental weight
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AbstractFetal growth is dependent on oxygen and nutrients that are transferred from the mother by the placenta. Placental weight is an indicator of placental function. Johanne Dypvik has explored how placental weight may be associated with diabetes, preeclampsia and infant death. Data from the Medical Birth Registry of Norway were used in all three studies. We found that placental weight was higher in preeclamptic pregnancies with diabetes and lower in preeclamptic pregnancies without diabetes than in non-preeclamptic pregnancies. Hence, it is possible that the biological mechanisms that cause preeclampsia may differ between women with diabetes and women without diabetes. Prediction of the women who will develop preeclampsia in a second pregnancy may be difficult. We found that low placental weight in the first pregnancy increased the risk of preeclampsia in the second pregnancy. Additionally, high placental weight in the first pregnancy increased the risk of developing term preeclampsia in the second pregnancy in women without previous preeclampsia. Information about placental weight in the first pregnancy may therefore contribute to identify women at increased risk of developing preeclampsia in the second pregnancy. Low placental weight seemed to increase the risk of infant death independent of gestational age at birth. However, the results differed for infants born in gestational weeks 29-32. In these infants, high placental weight doubled the risk of infant death. Information about placental weight could help in the identification of infants at increased risk of infant death.
List of papers
|Paper I: Preeclampsia in pregnancies with and without diabetes: the associations with placental weight. A population study of 655 842 pregnancies. Dypvik J, Strøm–Roum EM, Haavaldsen C, Vatten LJ, Eskild A. Acta Obstet Gynecol Scand. 2016;95:217–24. DOI: 10.1111/aogs.12795. The paper is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1111/aogs.12795|
|Paper II: Placental weight in the first pregnancy and risk for preeclampsia in the second pregnancy: A population–based study of 186 859 women. Dypvik J and Larsen S, Haavaldsen C, Jukic AM, Vatten LJ, Eskild A. Eur J Obstet Gynecol Reprod Biol. 2017;214:184–189. DOI: 10.1016/j.ejogrb.2017.05.010. The paper is included in the thesis. Also available at: https://doi.org/10.1016/j.ejogrb.2017.05.010|
|Paper III: Placental weight and risk for infant death. Dypvik J, Larsen S, Haavaldsen C, Eskild A. Submitted May 2018. To be published. The paper is not available in DUO awaiting publishing.|