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dc.date.accessioned2019-02-05T12:27:07Z
dc.date.available2019-02-05T12:27:07Z
dc.date.created2018-07-20T10:01:59Z
dc.date.issued2018
dc.identifier.citationChristensen, Erik Taylor, Myra Zulu, Siphosenkosi Gift Lillebø, Kristine Gundersen, Svein Gunnar Holmen, Sigve Kleppa, Elisabeth Vennervald, Birgitte Jyding Ndhlovu, Patricia Doris Kjetland, Eyrun Floerecke . Seasonal variations in schistosoma haematobium egg excretion in school-age girls in rural Kwazulu-Natal province, South Africa. South African Medical Journal. 2018, 108(4), 352-355
dc.identifier.urihttp://hdl.handle.net/10852/66395
dc.description.abstractBackground. A predominant feature of Schistosoma haematobium infection is urinary egg excretion, and microscopic egg detection remains the accepted standard field diagnostic tool. Praziquantel is the drug of choice for schistosomiasis, and the World Health Organization recommends that it should be administered to all children >4 years of age living in schistosomiasis-endemic areas. The frequency of mass drug administration depends on the prevalence rate in the community. Urinary schistosome egg output has a day-to-day and hour-to-hour intrasubject variation. Therefore, it is important to assess possible seasonal variations in egg excretion to improve the planning of drug treatment. Objectives. To assess the influence of seasonality on urinary schistosome egg excretion in South Africa (SA). Methods. We performed a prospective cohort study, exploring seasonal variations of S. haematobium egg excretion in 184 girls aged 10 - 12 years from randomly selected schools in a rural area of KwaZulu-Natal Province, SA. The area has a subtropical climate characterised by a cool dry season and a hot humid season. For children, water contact is higher in the latter season. At baseline, 108 girls were examined in the hot season, and 76 in the cold season. In the next year’s cold season the untreated patients were re-investigated before treatment. Results. There was a decrease in infection in the group initially tested in the hot season compared with the group tested in the cold season at both time points when adjusted for age and water contact (adjusted odds ratio 3.61 (95% confidence interval 1.14 - 11.44); p=0.03). Conclusions. This unique study shows that schistosomiasis prevalence determined by microscopy exhibits seasonal variation, with a higher prevalence in the hot rainy season. Precise community prevalence estimations are key in decisions to treat communities. There was significantly lower egg output in the cold season, and sampling in that season may therefore underestimate the prevalence of urinary schistosomiasis. The study indicates that sampling in SA should be done in the hot season.en_US
dc.languageEN
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleSeasonal variations in schistosoma haematobium egg excretion in school-age girls in rural Kwazulu-Natal province, South Africaen_US
dc.typeJournal articleen_US
dc.creator.authorChristensen, Erik
dc.creator.authorTaylor, Myra
dc.creator.authorZulu, Siphosenkosi Gift
dc.creator.authorLillebø, Kristine
dc.creator.authorGundersen, Svein Gunnar
dc.creator.authorHolmen, Sigve
dc.creator.authorKleppa, Elisabeth
dc.creator.authorVennervald, Birgitte Jyding
dc.creator.authorNdhlovu, Patricia Doris
dc.creator.authorKjetland, Eyrun Floerecke
cristin.unitcode185,53,11,14
cristin.unitnameInfeksjonsmedisinsk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1598053
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=South African Medical Journal&rft.volume=108&rft.spage=352&rft.date=2018
dc.identifier.jtitleSouth African Medical Journal
dc.identifier.volume108
dc.identifier.issue4
dc.identifier.startpage352
dc.identifier.endpage355
dc.identifier.doihttp://dx.doi.org/10.7196/SAMJ.2018.v108i4.12775
dc.identifier.urnURN:NBN:no-69611
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0256-9574
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/66395/1/Christensen%2Bet%2Bal.pdf
dc.type.versionPublishedVersion


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