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dc.date.accessioned2019-01-31T13:25:09Z
dc.date.available2019-01-31T13:25:09Z
dc.date.created2018-08-10T11:07:47Z
dc.date.issued2018
dc.identifier.citationVan Erp, Theo G.M. Walton, Esther Hibar, Derrek Schmaal, Lianne Jiang, Wenhao Glahn, David C. Pearlson, Godfrey D. Yao, Nailin Fukunaga, Masaki Hashimoto, Ryota Okada, Naohiro Yamamori, Hidenaga Bustillo, Juan R. Clark, Vincent P. Agartz, Ingrid Mueller, Bryon A. Cahn, Wiepke de Zwarte, Sonja M.C. Hulshoff Pol, Hilleke E. Kahn, René S. Ophoff, Roel A. van Haren, Neeltje E.M. Andreassen, Ole Andreas Dale, Anders Doan, Nhat Trung Gurholt, Tiril Pedersen Hartberg, Cecilie Bhandari Haukvik, Unn Kristin H. Jørgensen, Kjetil Nordbø Lagerberg, Trine Vik Melle, Ingrid Westlye, Lars Tjelta Gruber, Oliver Kraemer, Bernd Richter, Anja Zilles, David Calhoun, Vince D. Crespo-Facorro, Benedicto Roiz-Santiañez, Roberto Tordesillas-Gutiérrez, Diana Loughland, Carmel Carr, Vaughan J. Catts, Stanley Cropley, Vanessa L. Fullerton, Janice M. Green, Melissa J. Henskens, Frans A. Jablensky, Assen Lenroot, Rhoshel K. Mowry, Bryan J. Michie, Patricia T. Pantelis, Christos Quide, Yann Schall, Ulrich Scott, Rodney J. Cairns, Murray J. Seal, Marc Tooney, Paul A. Rasser, Paul E. Cooper, Gavin Shannon Weickert, Cynthia Weickert, Thomas W. Morris, Derek W. Hong, Elliot Kochunov, Peter Beard, Lauren M. Gur, Raquel E. Gur, Ruben C. Satterthwaite, Theodore D Wolf, Daniel H. Belger, Aysenil Brown, Gregory G. Ford, Judith M. Macciardi, Fabio Mathalon, Daniel H. O'Leary, Daniel S. Potkin, Steven G. Preda, Adrian Voyvodic, James Lim, Kelvin O. McEwen, Sarah Yang, Fude Tan, Yunlong Tan, Shuping Wang, Zhiren Fan, Fengmei Chen, Jingxu Xiang, Hong Tang, Shiyou Guo, Hua Wan, Ping Wei, Dong Bockholt, Henry J. Ehrlich, Stefan Wolthusen, Rick P.F. King, Margaret D. Shoemaker, Jody M. Sponheim, Scott R. De Haan, Lieuwe Koenders, Laura Machielsen, Marise W. van Amelsvoort, Therese Veltman, Dick J. Assogna, Francesca Banaj, Nerisa de Rossi, Pietro Iorio, Mariangela Piras, Fabrizio Spalletta, Gianfranco McKenna, Peter J. Pomarol-Clotet, Edith Salvador, Raymond Corvin, Aiden Donohoe, Gary Kelly, Sinead Whelan, Christopher D. Dickie, Erin W. Rotenberg, David Voineskos, Aristotle N. Ciufolini, Simone Radua, Joaquim Dazzan, Paola Murray, Robin Reis Marques, Tiago Simmons, Andrew Borgwardt, Stefan Egloff, Laura Harrisberger, Fabienne Riecher-Rössler, Anita Smieskova, Renata Alpert, Kathryn I. Wang, Lei Jönsson, Erik Gunnar Koops, Sanne Sommer, Iris Else Clara Bertolino, Alessandro Bonvino, Aurora Di Giorgio, Annabella Neilson, Emma Mayer, Andrew R. Stephen, Julia M. Kwon, Jun Soo Yun, Je-Yeon Cannon, Dara M. McDonald, Colm Lebedeva, Irina Tomyshev, Alexander S. Akhadov, Tolibjohn Kaleda, Vasily Fatouros-Bergman, Helena Flyckt, Lena . Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. 2018
dc.identifier.urihttp://hdl.handle.net/10852/66369
dc.description.abstractBackground: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. Methods: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide. Results: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen’s d = −0.530/−0.516) and smaller surface area (left/right hemisphere: Cohen’s d = −0.251/−0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset. Conclusions: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.en_US
dc.languageEN
dc.publisherElsevier Science
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleCortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortiumen_US
dc.typeJournal articleen_US
dc.creator.authorVan Erp, Theo G.M.
dc.creator.authorWalton, Esther
dc.creator.authorHibar, Derrek
dc.creator.authorSchmaal, Lianne
dc.creator.authorJiang, Wenhao
dc.creator.authorGlahn, David C.
dc.creator.authorPearlson, Godfrey D.
dc.creator.authorYao, Nailin
dc.creator.authorFukunaga, Masaki
dc.creator.authorHashimoto, Ryota
dc.creator.authorOkada, Naohiro
dc.creator.authorYamamori, Hidenaga
dc.creator.authorBustillo, Juan R.
dc.creator.authorClark, Vincent P.
dc.creator.authorAgartz, Ingrid
dc.creator.authorMueller, Bryon A.
dc.creator.authorCahn, Wiepke
dc.creator.authorde Zwarte, Sonja M.C.
dc.creator.authorHulshoff Pol, Hilleke E.
dc.creator.authorKahn, René S.
dc.creator.authorOphoff, Roel A.
dc.creator.authorvan Haren, Neeltje E.M.
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorDale, Anders
dc.creator.authorDoan, Nhat Trung
dc.creator.authorGurholt, Tiril Pedersen
dc.creator.authorHartberg, Cecilie Bhandari
dc.creator.authorHaukvik, Unn Kristin H.
dc.creator.authorJørgensen, Kjetil Nordbø
dc.creator.authorLagerberg, Trine Vik
dc.creator.authorMelle, Ingrid
dc.creator.authorWestlye, Lars Tjelta
dc.creator.authorGruber, Oliver
dc.creator.authorKraemer, Bernd
dc.creator.authorRichter, Anja
dc.creator.authorZilles, David
dc.creator.authorCalhoun, Vince D.
dc.creator.authorCrespo-Facorro, Benedicto
dc.creator.authorRoiz-Santiañez, Roberto
dc.creator.authorTordesillas-Gutiérrez, Diana
dc.creator.authorLoughland, Carmel
dc.creator.authorCarr, Vaughan J.
dc.creator.authorCatts, Stanley
dc.creator.authorCropley, Vanessa L.
dc.creator.authorFullerton, Janice M.
dc.creator.authorGreen, Melissa J.
dc.creator.authorHenskens, Frans A.
dc.creator.authorJablensky, Assen
dc.creator.authorLenroot, Rhoshel K.
dc.creator.authorMowry, Bryan J.
dc.creator.authorMichie, Patricia T.
dc.creator.authorPantelis, Christos
dc.creator.authorQuide, Yann
dc.creator.authorSchall, Ulrich
dc.creator.authorScott, Rodney J.
dc.creator.authorCairns, Murray J.
dc.creator.authorSeal, Marc
dc.creator.authorTooney, Paul A.
dc.creator.authorRasser, Paul E.
dc.creator.authorCooper, Gavin
dc.creator.authorShannon Weickert, Cynthia
dc.creator.authorWeickert, Thomas W.
dc.creator.authorMorris, Derek W.
dc.creator.authorHong, Elliot
dc.creator.authorKochunov, Peter
dc.creator.authorBeard, Lauren M.
dc.creator.authorGur, Raquel E.
dc.creator.authorGur, Ruben C.
dc.creator.authorSatterthwaite, Theodore D
dc.creator.authorWolf, Daniel H.
dc.creator.authorBelger, Aysenil
dc.creator.authorBrown, Gregory G.
dc.creator.authorFord, Judith M.
dc.creator.authorMacciardi, Fabio
dc.creator.authorMathalon, Daniel H.
dc.creator.authorO'Leary, Daniel S.
dc.creator.authorPotkin, Steven G.
dc.creator.authorPreda, Adrian
dc.creator.authorVoyvodic, James
dc.creator.authorLim, Kelvin O.
dc.creator.authorMcEwen, Sarah
dc.creator.authorYang, Fude
dc.creator.authorTan, Yunlong
dc.creator.authorTan, Shuping
dc.creator.authorWang, Zhiren
dc.creator.authorFan, Fengmei
dc.creator.authorChen, Jingxu
dc.creator.authorXiang, Hong
dc.creator.authorTang, Shiyou
dc.creator.authorGuo, Hua
dc.creator.authorWan, Ping
dc.creator.authorWei, Dong
dc.creator.authorBockholt, Henry J.
dc.creator.authorEhrlich, Stefan
dc.creator.authorWolthusen, Rick P.F.
dc.creator.authorKing, Margaret D.
dc.creator.authorShoemaker, Jody M.
dc.creator.authorSponheim, Scott R.
dc.creator.authorDe Haan, Lieuwe
dc.creator.authorKoenders, Laura
dc.creator.authorMachielsen, Marise W.
dc.creator.authorvan Amelsvoort, Therese
dc.creator.authorVeltman, Dick J.
dc.creator.authorAssogna, Francesca
dc.creator.authorBanaj, Nerisa
dc.creator.authorde Rossi, Pietro
dc.creator.authorIorio, Mariangela
dc.creator.authorPiras, Fabrizio
dc.creator.authorSpalletta, Gianfranco
dc.creator.authorMcKenna, Peter J.
dc.creator.authorPomarol-Clotet, Edith
dc.creator.authorSalvador, Raymond
dc.creator.authorCorvin, Aiden
dc.creator.authorDonohoe, Gary
dc.creator.authorKelly, Sinead
dc.creator.authorWhelan, Christopher D.
dc.creator.authorDickie, Erin W.
dc.creator.authorRotenberg, David
dc.creator.authorVoineskos, Aristotle N.
dc.creator.authorCiufolini, Simone
dc.creator.authorRadua, Joaquim
dc.creator.authorDazzan, Paola
dc.creator.authorMurray, Robin
dc.creator.authorReis Marques, Tiago
dc.creator.authorSimmons, Andrew
dc.creator.authorBorgwardt, Stefan
dc.creator.authorEgloff, Laura
dc.creator.authorHarrisberger, Fabienne
dc.creator.authorRiecher-Rössler, Anita
dc.creator.authorSmieskova, Renata
dc.creator.authorAlpert, Kathryn I.
dc.creator.authorWang, Lei
dc.creator.authorJönsson, Erik Gunnar
dc.creator.authorKoops, Sanne
dc.creator.authorSommer, Iris Else Clara
dc.creator.authorBertolino, Alessandro
dc.creator.authorBonvino, Aurora
dc.creator.authorDi Giorgio, Annabella
dc.creator.authorNeilson, Emma
dc.creator.authorMayer, Andrew R.
dc.creator.authorStephen, Julia M.
dc.creator.authorKwon, Jun Soo
dc.creator.authorYun, Je-Yeon
dc.creator.authorCannon, Dara M.
dc.creator.authorMcDonald, Colm
dc.creator.authorLebedeva, Irina
dc.creator.authorTomyshev, Alexander S.
dc.creator.authorAkhadov, Tolibjohn
dc.creator.authorKaleda, Vasily
dc.creator.authorFatouros-Bergman, Helena
dc.creator.authorFlyckt, Lena
cristin.unitcode185,53,10,11
cristin.unitnameSenter for psykoseforskning
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1600958
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biological Psychiatry&rft.volume=&rft.spage=&rft.date=2018
dc.identifier.jtitleBiological Psychiatry
dc.identifier.pagecount11
dc.identifier.doihttp://dx.doi.org/10.1016/j.biopsych.2018.04.023
dc.identifier.urnURN:NBN:no-69574
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0006-3223
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/66369/1/1-s2.0-S0006322318315178-main.pdf
dc.type.versionPublishedVersion
dc.relation.projectNFR/249795


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