Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
dc.date.accessioned | 2019-01-31T13:25:09Z | |
dc.date.available | 2019-01-31T13:25:09Z | |
dc.date.created | 2018-08-10T11:07:47Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Van Erp, Theo G.M. Walton, Esther Hibar, Derrek Schmaal, Lianne Jiang, Wenhao Glahn, David C. Pearlson, Godfrey D. Yao, Nailin Fukunaga, Masaki Hashimoto, Ryota Okada, Naohiro Yamamori, Hidenaga Bustillo, Juan R. Clark, Vincent P. Agartz, Ingrid Mueller, Bryon A. Cahn, Wiepke de Zwarte, Sonja M.C. Hulshoff Pol, Hilleke E. Kahn, René S. Ophoff, Roel A. van Haren, Neeltje E.M. Andreassen, Ole Andreas Dale, Anders Doan, Nhat Trung Gurholt, Tiril Pedersen Hartberg, Cecilie Bhandari Haukvik, Unn Kristin H. Jørgensen, Kjetil Nordbø Lagerberg, Trine Vik Melle, Ingrid Westlye, Lars Tjelta Gruber, Oliver Kraemer, Bernd Richter, Anja Zilles, David Calhoun, Vince D. Crespo-Facorro, Benedicto Roiz-Santiañez, Roberto Tordesillas-Gutiérrez, Diana Loughland, Carmel Carr, Vaughan J. Catts, Stanley Cropley, Vanessa L. Fullerton, Janice M. Green, Melissa J. Henskens, Frans A. Jablensky, Assen Lenroot, Rhoshel K. Mowry, Bryan J. Michie, Patricia T. Pantelis, Christos Quide, Yann Schall, Ulrich Scott, Rodney J. Cairns, Murray J. Seal, Marc Tooney, Paul A. Rasser, Paul E. Cooper, Gavin Shannon Weickert, Cynthia Weickert, Thomas W. Morris, Derek W. Hong, Elliot Kochunov, Peter Beard, Lauren M. Gur, Raquel E. Gur, Ruben C. Satterthwaite, Theodore D Wolf, Daniel H. Belger, Aysenil Brown, Gregory G. Ford, Judith M. Macciardi, Fabio Mathalon, Daniel H. O'Leary, Daniel S. Potkin, Steven G. Preda, Adrian Voyvodic, James Lim, Kelvin O. McEwen, Sarah Yang, Fude Tan, Yunlong Tan, Shuping Wang, Zhiren Fan, Fengmei Chen, Jingxu Xiang, Hong Tang, Shiyou Guo, Hua Wan, Ping Wei, Dong Bockholt, Henry J. Ehrlich, Stefan Wolthusen, Rick P.F. King, Margaret D. Shoemaker, Jody M. Sponheim, Scott R. De Haan, Lieuwe Koenders, Laura Machielsen, Marise W. van Amelsvoort, Therese Veltman, Dick J. Assogna, Francesca Banaj, Nerisa de Rossi, Pietro Iorio, Mariangela Piras, Fabrizio Spalletta, Gianfranco McKenna, Peter J. Pomarol-Clotet, Edith Salvador, Raymond Corvin, Aiden Donohoe, Gary Kelly, Sinead Whelan, Christopher D. Dickie, Erin W. Rotenberg, David Voineskos, Aristotle N. Ciufolini, Simone Radua, Joaquim Dazzan, Paola Murray, Robin Reis Marques, Tiago Simmons, Andrew Borgwardt, Stefan Egloff, Laura Harrisberger, Fabienne Riecher-Rössler, Anita Smieskova, Renata Alpert, Kathryn I. Wang, Lei Jönsson, Erik Gunnar Koops, Sanne Sommer, Iris Else Clara Bertolino, Alessandro Bonvino, Aurora Di Giorgio, Annabella Neilson, Emma Mayer, Andrew R. Stephen, Julia M. Kwon, Jun Soo Yun, Je-Yeon Cannon, Dara M. McDonald, Colm Lebedeva, Irina Tomyshev, Alexander S. Akhadov, Tolibjohn Kaleda, Vasily Fatouros-Bergman, Helena Flyckt, Lena . Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. 2018 | |
dc.identifier.uri | http://hdl.handle.net/10852/66369 | |
dc.description.abstract | Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. Methods: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide. Results: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen’s d = −0.530/−0.516) and smaller surface area (left/right hemisphere: Cohen’s d = −0.251/−0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset. Conclusions: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia. | en_US |
dc.language | EN | |
dc.publisher | Elsevier Science | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Van Erp, Theo G.M. | |
dc.creator.author | Walton, Esther | |
dc.creator.author | Hibar, Derrek | |
dc.creator.author | Schmaal, Lianne | |
dc.creator.author | Jiang, Wenhao | |
dc.creator.author | Glahn, David C. | |
dc.creator.author | Pearlson, Godfrey D. | |
dc.creator.author | Yao, Nailin | |
dc.creator.author | Fukunaga, Masaki | |
dc.creator.author | Hashimoto, Ryota | |
dc.creator.author | Okada, Naohiro | |
dc.creator.author | Yamamori, Hidenaga | |
dc.creator.author | Bustillo, Juan R. | |
dc.creator.author | Clark, Vincent P. | |
dc.creator.author | Agartz, Ingrid | |
dc.creator.author | Mueller, Bryon A. | |
dc.creator.author | Cahn, Wiepke | |
dc.creator.author | de Zwarte, Sonja M.C. | |
dc.creator.author | Hulshoff Pol, Hilleke E. | |
dc.creator.author | Kahn, René S. | |
dc.creator.author | Ophoff, Roel A. | |
dc.creator.author | van Haren, Neeltje E.M. | |
dc.creator.author | Andreassen, Ole Andreas | |
dc.creator.author | Dale, Anders | |
dc.creator.author | Doan, Nhat Trung | |
dc.creator.author | Gurholt, Tiril Pedersen | |
dc.creator.author | Hartberg, Cecilie Bhandari | |
dc.creator.author | Haukvik, Unn Kristin H. | |
dc.creator.author | Jørgensen, Kjetil Nordbø | |
dc.creator.author | Lagerberg, Trine Vik | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | Gruber, Oliver | |
dc.creator.author | Kraemer, Bernd | |
dc.creator.author | Richter, Anja | |
dc.creator.author | Zilles, David | |
dc.creator.author | Calhoun, Vince D. | |
dc.creator.author | Crespo-Facorro, Benedicto | |
dc.creator.author | Roiz-Santiañez, Roberto | |
dc.creator.author | Tordesillas-Gutiérrez, Diana | |
dc.creator.author | Loughland, Carmel | |
dc.creator.author | Carr, Vaughan J. | |
dc.creator.author | Catts, Stanley | |
dc.creator.author | Cropley, Vanessa L. | |
dc.creator.author | Fullerton, Janice M. | |
dc.creator.author | Green, Melissa J. | |
dc.creator.author | Henskens, Frans A. | |
dc.creator.author | Jablensky, Assen | |
dc.creator.author | Lenroot, Rhoshel K. | |
dc.creator.author | Mowry, Bryan J. | |
dc.creator.author | Michie, Patricia T. | |
dc.creator.author | Pantelis, Christos | |
dc.creator.author | Quide, Yann | |
dc.creator.author | Schall, Ulrich | |
dc.creator.author | Scott, Rodney J. | |
dc.creator.author | Cairns, Murray J. | |
dc.creator.author | Seal, Marc | |
dc.creator.author | Tooney, Paul A. | |
dc.creator.author | Rasser, Paul E. | |
dc.creator.author | Cooper, Gavin | |
dc.creator.author | Shannon Weickert, Cynthia | |
dc.creator.author | Weickert, Thomas W. | |
dc.creator.author | Morris, Derek W. | |
dc.creator.author | Hong, Elliot | |
dc.creator.author | Kochunov, Peter | |
dc.creator.author | Beard, Lauren M. | |
dc.creator.author | Gur, Raquel E. | |
dc.creator.author | Gur, Ruben C. | |
dc.creator.author | Satterthwaite, Theodore D | |
dc.creator.author | Wolf, Daniel H. | |
dc.creator.author | Belger, Aysenil | |
dc.creator.author | Brown, Gregory G. | |
dc.creator.author | Ford, Judith M. | |
dc.creator.author | Macciardi, Fabio | |
dc.creator.author | Mathalon, Daniel H. | |
dc.creator.author | O'Leary, Daniel S. | |
dc.creator.author | Potkin, Steven G. | |
dc.creator.author | Preda, Adrian | |
dc.creator.author | Voyvodic, James | |
dc.creator.author | Lim, Kelvin O. | |
dc.creator.author | McEwen, Sarah | |
dc.creator.author | Yang, Fude | |
dc.creator.author | Tan, Yunlong | |
dc.creator.author | Tan, Shuping | |
dc.creator.author | Wang, Zhiren | |
dc.creator.author | Fan, Fengmei | |
dc.creator.author | Chen, Jingxu | |
dc.creator.author | Xiang, Hong | |
dc.creator.author | Tang, Shiyou | |
dc.creator.author | Guo, Hua | |
dc.creator.author | Wan, Ping | |
dc.creator.author | Wei, Dong | |
dc.creator.author | Bockholt, Henry J. | |
dc.creator.author | Ehrlich, Stefan | |
dc.creator.author | Wolthusen, Rick P.F. | |
dc.creator.author | King, Margaret D. | |
dc.creator.author | Shoemaker, Jody M. | |
dc.creator.author | Sponheim, Scott R. | |
dc.creator.author | De Haan, Lieuwe | |
dc.creator.author | Koenders, Laura | |
dc.creator.author | Machielsen, Marise W. | |
dc.creator.author | van Amelsvoort, Therese | |
dc.creator.author | Veltman, Dick J. | |
dc.creator.author | Assogna, Francesca | |
dc.creator.author | Banaj, Nerisa | |
dc.creator.author | de Rossi, Pietro | |
dc.creator.author | Iorio, Mariangela | |
dc.creator.author | Piras, Fabrizio | |
dc.creator.author | Spalletta, Gianfranco | |
dc.creator.author | McKenna, Peter J. | |
dc.creator.author | Pomarol-Clotet, Edith | |
dc.creator.author | Salvador, Raymond | |
dc.creator.author | Corvin, Aiden | |
dc.creator.author | Donohoe, Gary | |
dc.creator.author | Kelly, Sinead | |
dc.creator.author | Whelan, Christopher D. | |
dc.creator.author | Dickie, Erin W. | |
dc.creator.author | Rotenberg, David | |
dc.creator.author | Voineskos, Aristotle N. | |
dc.creator.author | Ciufolini, Simone | |
dc.creator.author | Radua, Joaquim | |
dc.creator.author | Dazzan, Paola | |
dc.creator.author | Murray, Robin | |
dc.creator.author | Reis Marques, Tiago | |
dc.creator.author | Simmons, Andrew | |
dc.creator.author | Borgwardt, Stefan | |
dc.creator.author | Egloff, Laura | |
dc.creator.author | Harrisberger, Fabienne | |
dc.creator.author | Riecher-Rössler, Anita | |
dc.creator.author | Smieskova, Renata | |
dc.creator.author | Alpert, Kathryn I. | |
dc.creator.author | Wang, Lei | |
dc.creator.author | Jönsson, Erik Gunnar | |
dc.creator.author | Koops, Sanne | |
dc.creator.author | Sommer, Iris Else Clara | |
dc.creator.author | Bertolino, Alessandro | |
dc.creator.author | Bonvino, Aurora | |
dc.creator.author | Di Giorgio, Annabella | |
dc.creator.author | Neilson, Emma | |
dc.creator.author | Mayer, Andrew R. | |
dc.creator.author | Stephen, Julia M. | |
dc.creator.author | Kwon, Jun Soo | |
dc.creator.author | Yun, Je-Yeon | |
dc.creator.author | Cannon, Dara M. | |
dc.creator.author | McDonald, Colm | |
dc.creator.author | Lebedeva, Irina | |
dc.creator.author | Tomyshev, Alexander S. | |
dc.creator.author | Akhadov, Tolibjohn | |
dc.creator.author | Kaleda, Vasily | |
dc.creator.author | Fatouros-Bergman, Helena | |
dc.creator.author | Flyckt, Lena | |
cristin.unitcode | 185,53,10,11 | |
cristin.unitname | Senter for psykoseforskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1600958 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biological Psychiatry&rft.volume=&rft.spage=&rft.date=2018 | |
dc.identifier.jtitle | Biological Psychiatry | |
dc.identifier.pagecount | 11 | |
dc.identifier.doi | http://dx.doi.org/10.1016/j.biopsych.2018.04.023 | |
dc.identifier.urn | URN:NBN:no-69574 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0006-3223 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/66369/1/1-s2.0-S0006322318315178-main.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/249795 |
Files in this item
Appears in the following Collection
-
Psykologisk institutt [4349]
-
Institutt for klinisk medisin [10636]
-
CRIStin høstingsarkiv [30840]