Previous studies on risk factors for prolonged opioid use or misuse following surgery highlight mental health issues (particularly depression and anxiety) and pain as important risk factors. However, prospective studies are needed to better understand how these factors might increase the probability of problematic use of opioids. The main objectives of this pilot study were to gather information about the patient group; asses variance in selected measures and test the general set-up of a planned study, and to uncover potential glitches and oversights. Secondary objectives were to assess how pre-operative measures of distress, pain, pain interference, and history of opioid use relate to immediate post-operative use of analgesics, and in particular opiate drugs. This was a prospective study. The patients were measured at four different times. T1) a few weeks before surgery, T2) a few hours before surgery, T3) on the operating table three minutes before surgery and T4) the day after surgery. At all time points, we collected measures on negative affect. Pain intensity and pain interference were measured at T1, T2 and T4. At T3 we also measured acute effects of the opioid drug remifentanil, administered for ~3 minutes before the application of anesthesia. Outcome measures were i) whether opioid analgesics were ingested at home after surgery, and ii) the total of analgesic pills (Oxynorm and paracetamol) ingested day one following surgery. Despite the identification of many necessary improvements to the study protocol, the main result of the pilot study revealed that the study is generally feasible. The interviews at T3 and T4 were successful for both research staff and patients. Further, our preliminary analyses showed levels of pain interference weeks before surgery, and type of operation, to be important predictors for analgesic intake the day after surgery. Higher levels of pain interference were also evident when the group who chose to ingest opioids post-surgery were compared to patients who received opioid analgesics which they did not ingest. This pilot study suggests that a larger, prospective study including measures before and after surgery, as well as the novel design aspect of including measures of opioid drug effects collected at the operating table, is feasible. I make a series of recommendations for the design of the main study.