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dc.date.accessioned2019-01-17T15:40:36Z
dc.date.available2019-01-17T15:40:36Z
dc.date.created2018-11-30T10:09:48Z
dc.date.issued2018
dc.identifier.citationMazzawi, Tarek Lied, Gülen Arslan Sangnes, Dag André El-Salhy, Magdy Hov, Johannes Espolin Roksund Gilja, Odd Helge Hatlebakk, Jan Gunnar Hausken, Trygve . The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation. PLoS ONE. 2018, 13(11), 1-17
dc.identifier.urihttp://hdl.handle.net/10852/66193
dc.description.abstractBackground: Gut microbiota alterations are important in irritable bowel syndrome (IBS). The aim was to investigate the effect of fecal microbiota transplantation (FMT) on gut microbiota and the symptoms in patients with IBS. Material and methods: The study included 13 IBS patients according to Rome III criteria and 13 healthy donors. Freshly donated feces were administered to the descending part of the duodenum via a gastroscope. Feces were collected from donors and patients before FMT, and from the patients at 1, 3 and 12 weeks and donors and patients at 20/28 weeks after FMT. Microbiota analysis was performed using GA-map Dysbiosis test (Genetic Analysis AS, Oslo, Norway). The patients completed the following questionnaires before and at the aforementioned weeks after FMT: IBS Symptom Questionnaire (IBS-SQ), IBS-Symptom Severity Scoring system (IBS-SSS), Short Form of Nepean Dyspepsia Index (SF-NDI), Bristol stool form scale, the Eysenck Personality Questionnaire-Neuroticism and Hospital Anxiety and Depression. Results: Donors and IBS patients had significantly different bacterial strain signals before FMT (Ruminococcus gnavus, Actinobacteria and Bifidobacteria) that became non-significant after 3 weeks following FMT. The changes in gut microbiota were similar between donors and patients at 20/28 weeks after FMT. Thus, patients’ microbiota profiles became more-or-less similar to donors. The scores of all the questionnaires were significantly improved at all time points following FMT. No reported adverse effects. Conclusions: FMT was associated with a change in gut microbiota and improvement in IBS symptoms and quality of life lasting for up to 28 weeks.en_US
dc.languageEN
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantationen_US
dc.typeJournal articleen_US
dc.creator.authorMazzawi, Tarek
dc.creator.authorLied, Gülen Arslan
dc.creator.authorSangnes, Dag André
dc.creator.authorEl-Salhy, Magdy
dc.creator.authorHov, Johannes Espolin Roksund
dc.creator.authorGilja, Odd Helge
dc.creator.authorHatlebakk, Jan Gunnar
dc.creator.authorHausken, Trygve
cristin.unitcode185,53,48,12
cristin.unitnameAvdeling for transplantasjonsmedisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1637338
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=13&rft.spage=1&rft.date=2018
dc.identifier.jtitlePLoS ONE
dc.identifier.volume13
dc.identifier.issue11
dc.identifier.startpage1
dc.identifier.endpage17
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0194904
dc.identifier.urnURN:NBN:no-69406
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/66193/1/journal.pone.0194904.pdf
dc.type.versionPublishedVersion


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