dc.date.accessioned | 2019-01-17T14:07:31Z | |
dc.date.available | 2019-01-17T14:07:31Z | |
dc.date.created | 2018-11-07T13:59:24Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Cai, Tommaso Cocci, Andrea Tiscione, Daniele Puglisi, Marco Di Maida, Fabrizio Malossini, Gianni Verze, Paolo Palmieri, Alessandro Mirone, Vincenzo Johansen, Truls Erik Bjerklund . L-Methionine associated with Hibiscus sabdariffa and Boswellia serrata extracts are not inferior to antibiotic treatment for symptoms relief in patients affected by recurrent uncomplicated urinary tract infections: Focus on antibiotic-sparing approach. Archivio italiano di urologia, andrologia. 2018, 9(2), 97-100 | |
dc.identifier.uri | http://hdl.handle.net/10852/66184 | |
dc.description.abstract | Objective: To evaluate the efficacy of a phytotherapic combination of L-Methionine associated with Hibiscus sabdariffa and Boswellia serrata for treatment of acute episodes of uncomplicated urinary tract infections (UTI) in women affected by recurrent UTIs.
Materials and methods: In this randomized phase III clinical trial, adult females with uncomplicated UTI were enrolled into one of the following treatment groups: Group A: phytotherapic combination 1 tablet in the morning and 1 tablet in the evening for 7 days; Group B: Short term antibiotic treatment according to international guidelines recommendations. At baseline, all patients were evaluated by a urologist and quality of life (QoL) questionnaires and mid-stream urine culture. Same clinical and laboratory investigations were repeated at each follow-up visit.
Results: Forty-six patients were enrolled in Group A and 47 in Group B. At the first follow-up (30 days), both groups showed a statistically significant improvement in quality of life scores as compared with baseline assessment [Group A: (QoL 94.3 VS 98.5 p < 0.001); Group B: (QoL 94.5 VS 98.7 p < 0.001)]. An improvement from baseline was also seen at the second followup evaluation after 3 months [Group A: (QoL 94.3 VS 99.1 p < 0.001); Group B: (QoL 94.5 VS 98.1 p < 0.001)]. At the second follow-up visit, a statistically significant difference in QoL was reported between the two groups (99.1 VS 98.1; p < 0.003) and a transition from UTI to asymptomatic bacteriuria (ABU) was observed 12 of 46 (26%) patients in Group A, while no patients in Group B demonstrated ABU (p = 0.007).
Conclusions: Here, we demonstrated that this phytotherapic combination is able, in comparison to antibiotic treatment, to improve patients quality of life, reducing symptoms in acute setting and preventing the recurrences. Interestingly, a significantly higher proportion of patients in the phytotherapy group had ABU after three months. Our findings are of great interest in an antibiotic stewardship perspective. | en_US |
dc.language | EN | |
dc.publisher | Masson SpA | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | L-Methionine associated with Hibiscus sabdariffa and Boswellia serrata extracts are not inferior to antibiotic treatment for symptoms relief in patients affected by recurrent uncomplicated urinary tract infections: Focus on antibiotic-sparing approach | en_US |
dc.title.alternative | ENEngelskEnglishL-Methionine associated with Hibiscus sabdariffa and Boswellia serrata extracts are not inferior to antibiotic treatment for symptoms relief in patients affected by recurrent uncomplicated urinary tract infections: Focus on antibiotic-sparing approach | |
dc.type | Journal article | en_US |
dc.creator.author | Cai, Tommaso | |
dc.creator.author | Cocci, Andrea | |
dc.creator.author | Tiscione, Daniele | |
dc.creator.author | Puglisi, Marco | |
dc.creator.author | Di Maida, Fabrizio | |
dc.creator.author | Malossini, Gianni | |
dc.creator.author | Verze, Paolo | |
dc.creator.author | Palmieri, Alessandro | |
dc.creator.author | Mirone, Vincenzo | |
dc.creator.author | Johansen, Truls Erik Bjerklund | |
cristin.unitcode | 185,53,48,11 | |
cristin.unitname | Avdeling for urologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1627998 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Archivio italiano di urologia, andrologia&rft.volume=9&rft.spage=97&rft.date=2018 | |
dc.identifier.jtitle | Archivio italiano di urologia, andrologia | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 97 | |
dc.identifier.endpage | 100 | |
dc.identifier.doi | http://dx.doi.org/10.4081/aiua.2018.2.97 | |
dc.identifier.urn | URN:NBN:no-69403 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1124-3562 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/66184/2/7424-35424-1-PB.pdf | |
dc.type.version | PublishedVersion | |