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dc.date.accessioned2018-12-21T13:36:36Z
dc.date.available2018-12-21T13:36:36Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10852/65978
dc.description.abstractThis thesis contributed to the field of human exposure to environmental pollutants called poly- and perfluoroalkyl substances (PFASs). Daily intakes of PFASs via ingestion, inhalation, and dermal absorption were estimated and compared to the internal doses. Overall, diet contributed most to the daily intake of PFASs, followed by house dust, indoor air, and dermal absorption, but some variations were observed on an individual basis. Significant associations between concentrations of PFASs measured in serum, and estimated intakes based on direct and indirect (precursor) exposure were observed. Measured serum concentrations and modelled serum concentrations based on external exposure estimates were in the same order of magnitude. The estimated daily intakes of PFASs in this study were lower than the health-based guidance values. Also, in this study, analytical methods have been developed and validated for the determinations of a broad range of PFASs in serum, plasma, whole blood, dried blood spot, and hand wipes. This study underlines the importance of performing studies considering multiple exposure pathways on an individual basis.en_US
dc.language.isoenen_US
dc.relation.haspartPaper I High throughput online solid phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry method for polyfluoroalkyl phosphate esters, perfluoroalkyl phosphonates, and other perfluoroalkyl substances in human serum, plasma, and whole blood Poothong, S., Lundanes, E., Thomsen, C., Haug, L. S., Analytica Chimica Acta, 2017, 957, 10-19. Published with an Attribution-NonCommercial-NoDerivatives 4.0 International License. The paper is alstå available in DUO: http://hdl.handle.net/10852/64644
dc.relation.haspartPaper II Distribution of novel and well-known poly- and perfluoroalkyl substances (PFASs) in human serum, plasma, and whole Blood Poothong, S., Thomsen, C., Padilla- Sánchez, J. A., Papadopoulou, E., Haug, L. S., Environmental Science & Technology, 2017, 51, 13388-13396. The paper is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1021/acs.est.7b03299
dc.relation.haspartPaper III Dried blood spots for reliable biomonitoring of poly- and perfluoroalkyl substances (PFASs) Poothong, S., Papadopoulou, E., Lundanes, E., Padilla-Sánchez, J. A., Thomsen, C., Haug, L. S., Manuscript, published as: Science of the Total Environment , 2018, 655, 1420-1426. The published version is available at: https://doi.org/10.1016/j.scitotenv.2018.11.214
dc.relation.haspartPaper IV Hand wipes: a useful tool for assessing human exposure to poly- and perfluoroalkyl substances (PFASs) through hand-to-mouth and dermal contacts Poothong, S., Padilla-Sánchez, J. A., Papadopoulou, E., Giovanoulis, G., Thomsen, C., Haug, L. S., (manuscript). To be published. The paper is not available in DUO awaiting publishing.
dc.relation.haspartPaper V Multiple pathways of human exposure to poly- and perfluoroalkyl substances (PFASs): from external exposure to human blood Poothong, S., Papadopoulou, E., Padilla-Sánchez, J. A., Thomsen, C., Haug, L. S., (manuscript). To be published. The paper is not available in DUO awaiting publishing.
dc.relation.urihttp://hdl.handle.net/10852/64644
dc.relation.urihttps://doi.org/10.1021/acs.est.7b03299
dc.relation.urihttps://doi.org/10.1016/j.scitotenv.2018.11.214
dc.titlePoly- and perfluoroalkyl substances (PFASs): from external exposure to human blooden_US
dc.typeDoctoral thesisen_US
dc.creator.authorPoothong, Somrutai
dc.identifier.urnURN:NBN:no-68469
dc.type.documentDoktoravhandlingen_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/65978/1/PhD-Poothong-DUO.pdf


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