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dc.date.accessioned2018-11-29T14:51:03Z
dc.date.available2018-11-29T14:51:03Z
dc.date.created2018-06-06T12:04:08Z
dc.date.issued2018
dc.identifier.citationGeiseler, Samuel Morland, Cecilie . The janus face of VEGF in stroke. International Journal of Molecular Sciences. 2018, 19:1362(5), 1-20
dc.identifier.urihttp://hdl.handle.net/10852/65838
dc.description.abstractThe family of vascular endothelial growth factors (VEGFs) are known for their regulation of vascularization. In the brain, VEGFs are important regulators of angiogenesis, neuroprotection and neurogenesis. Dysregulation of VEGFs is involved in a large number of neurodegenerative diseases and acute neurological insults, including stroke. Stroke is the main cause of acquired disabilities, and normally results from an occlusion of a cerebral artery or a hemorrhage, both leading to focal ischemia. Neurons in the ischemic core rapidly undergo necrosis. Cells in the penumbra are exposed to ischemia, but may be rescued if adequate perfusion is restored in time. The neuroprotective and angiogenic effects of VEGFs would theoretically make VEGFs ideal candidates for drug therapy in stroke. However, contradictory to what one might expect, endogenously upregulated levels of VEGF as well as the administration of exogenous VEGF is detrimental in acute stroke. This is probably due to VEGF-mediated blood–brain-barrier breakdown and vascular leakage, leading to edema and increased intracranial pressure as well as neuroinflammation. The key to understanding this Janus face of VEGF function in stroke may lie in the timing; the harmful effect of VEGFs on vessel integrity is transient, as both VEGF preconditioning and increased VEGF after the acute phase has a neuroprotective effect. The present review discusses the multifaceted action of VEGFs in stroke prevention and therapy.en_US
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe janus face of VEGF in strokeen_US
dc.title.alternativeENEngelskEnglishThe janus face of VEGF in stroke
dc.typeJournal articleen_US
dc.creator.authorGeiseler, Samuel
dc.creator.authorMorland, Cecilie
cristin.unitcode185,15,23,30
cristin.unitnameFarmasøytisk biovitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1589401
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International Journal of Molecular Sciences&rft.volume=19:1362&rft.spage=1&rft.date=2018
dc.identifier.jtitleInternational Journal of Molecular Sciences
dc.identifier.volume19:1362
dc.identifier.issue5
dc.identifier.startpage1
dc.identifier.endpage20
dc.identifier.doihttp://dx.doi.org/10.3390/ijms19051362
dc.identifier.urnURN:NBN:no-68267
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1422-0067
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/65838/2/The%2BJanus%2BFace%2Bof%2BVEGF%2Bin%2BStroke.pdf
dc.type.versionPublishedVersion


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