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dc.date.accessioned2018-11-29T14:36:34Z
dc.date.available2018-11-29T14:36:34Z
dc.date.created2018-08-01T12:30:23Z
dc.date.issued2018
dc.identifier.citationMcAdams, Tom A Hannigan, Laurie J Eilertsen, Espen Moen Gjerde, Line C. Ystrøm, Eivind Rijsdijk, Frühling V . Revisiting the Children-of-Twins Design: Improving Existing Models for the Exploration of Intergenerational Associations. Behavior Genetics. 2018, 48(5), 397-412
dc.identifier.urihttp://hdl.handle.net/10852/65836
dc.description.abstractDatasets comprising twins and their children can be a useful tool for understanding the nature of intergenerational associations between parent and offspring phenotypes. In the present article we explore structural equation models previously used to analyse Children-of-Twins data, highlighting some limitations and considerations. We then present new variants of these models, showing that extending the models to include multiple offspring per parent addresses several of the limitations discussed. Accompanying the updated models, we provide power calculations and demonstrate with application to simulated data. We then apply to intergenerational analyses of height and weight, using a sub-study of the Norwegian Mother and Child Cohort (MoBa); the Intergenerational Transmission of Risk (IToR) project, wherein all kinships in the MoBa data have been identified (a children-of-twins-and-siblings study). Finally, we consider how to interpret the findings of these models and discuss future directions.en_US
dc.languageEN
dc.publisherPlenum Publishing Corporation
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleRevisiting the Children-of-Twins Design: Improving Existing Models for the Exploration of Intergenerational Associationsen_US
dc.title.alternativeENEngelskEnglishRevisiting the Children-of-Twins Design: Improving Existing Models for the Exploration of Intergenerational Associations
dc.typeJournal articleen_US
dc.creator.authorMcAdams, Tom A
dc.creator.authorHannigan, Laurie J
dc.creator.authorEilertsen, Espen Moen
dc.creator.authorGjerde, Line C.
dc.creator.authorYstrøm, Eivind
dc.creator.authorRijsdijk, Frühling V
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1599334
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Behavior Genetics&rft.volume=48&rft.spage=397&rft.date=2018
dc.identifier.jtitleBehavior Genetics
dc.identifier.volume48
dc.identifier.issue5
dc.identifier.startpage397
dc.identifier.endpage412
dc.identifier.doihttp://dx.doi.org/10.1007/s10519-018-9912-4
dc.identifier.urnURN:NBN:no-68274
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0001-8244
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/65836/1/McAdams_2018_Rev.pdf
dc.type.versionPublishedVersion


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