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dc.date.accessioned2018-11-23T10:12:45Z
dc.date.available2018-11-23T10:12:45Z
dc.date.created2017-10-25T16:44:57Z
dc.date.issued2016
dc.identifier.citationWalhovd, Kristine B Fjell, Anders Martin Giedd, J Dale, AM Brown, Timothy T. . Through thick and thin: A need to reconcile contradictory results on trajectories in human cortical development. Cerebral Cortex. 2016
dc.identifier.urihttp://hdl.handle.net/10852/65630
dc.description.abstractUnderstanding how brain development normally proceeds is a premise of understanding neurodevelopmental disorders. This has sparked a wealth of magnetic resonance imaging (MRI) studies. Unfortunately, they are in marked disagreement on how the cerebral cortex matures. While cortical thickness increases for the first 8–9 years of life have repeatedly been reported, others find continuous cortical thinning from early childhood, at least from age 3 or 4 years. We review these inconsistencies, and discuss possible reasons, including the use of different scanners, recording parameters and analysis tools, and possible effects of variables such as head motion. When tested on the same subsample, 2 popular thickness estimation methods (CIVET and FreeSurfer) both yielded a continuous thickness decrease from 3 years. Importantly, MRI-derived measures of cortical development are merely our best current approximations, hence the term “apparent cortical thickness” may be preferable. We recommend strategies for reaching consensus in the field, including multimodal neuroimaging to measure phenomena using different techniques, for example, the use of T1 / T2 ratio, and data sharing to allow replication across analysis methods. As neurodevelopmental origins of early- and late-onset disease are increasingly recognized, resolving inconsistencies in brain maturation trajectories is important.en_US
dc.languageEN
dc.publisherOxford University Press
dc.titleThrough thick and thin: A need to reconcile contradictory results on trajectories in human cortical developmenten_US
dc.title.alternativeENEngelskEnglishThrough thick and thin: A need to reconcile contradictory results on trajectories in human cortical development
dc.typeJournal articleen_US
dc.creator.authorWalhovd, Kristine B
dc.creator.authorFjell, Anders Martin
dc.creator.authorGiedd, J
dc.creator.authorDale, AM
dc.creator.authorBrown, Timothy T.
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1507748
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral Cortex&rft.volume=&rft.spage=&rft.date=2016
dc.identifier.jtitleCerebral Cortex
dc.identifier.doihttp://dx.doi.org/10.1093/cercor/bhv301
dc.identifier.urnURN:NBN:no-68163
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1047-3211
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/65630/2/Walhovd%2Bet%2Bal%2BThrough%2Bthick%2Band%2Bthin_postprint.pdf
dc.type.versionAcceptedVersion


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