This article analyzes the determinants of job satisfaction among knowledge workers (KWs). Data from a representative sample of 14,096 employed workers from the European Social Survey (2010) are used for an empirical analysis drawing on multiple binary logistic regression models. Job satisfaction among KWs in 21 EU countries is found to be explained better by non-financial characteristics than by monetary rewards. Career advancement opportunities, flexible work schedules, colleague support, and work–family relations, as well as job security, emerge as central in explaining job satisfaction among KWs in our sample. Unlike the case for other workers (OWs), opportunities for further training and career experience are not determinants of job satisfaction among KWs. Management divisions in companies employing KWs would be well-advised to take these points into account.