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dc.date.accessioned2018-10-11T13:23:53Z
dc.date.available2018-10-11T13:23:53Z
dc.date.created2017-08-18T07:10:35Z
dc.date.issued2017
dc.identifier.citationSøberg, Kristoffer Moen, Line Victoria Skålhegg, Bjørn Steen Lærdahl, Jon Kristen . Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms.. PLoS ONE. 2017, 12:e0181091(7), 1-17
dc.identifier.urihttp://hdl.handle.net/10852/65136
dc.description.abstractThe 3’,5’-cyclic adenosine monophosphate (cAMP)-dependent protein kinase, or protein kinase A (PKA), pathway is one of the most versatile and best studied signaling pathways in eukaryotic cells. The two paralogous PKA catalytic subunits Cα and Cβ, encoded by the genes PRKACA and PRKACB, respectively, are among the best understood model kinases in signal transduction research. In this work, we explore and elucidate the evolution of the alternative 5’ exons and the splicing pattern giving rise to the numerous PKA catalytic subunit isoforms. In addition to the universally conserved Cα1/Cβ1 isoforms, we find kinase variants with short N-termini in all main vertebrate classes, including the sperm-specific Cα2 isoform found to be conserved in all mammals. We also describe, for the first time, a PKA Cα isoform with a long N-terminus, paralogous to the PKA Cβ2 N-terminus. An analysis of isoform-specific variation highlights residues and motifs that are likely to be of functional importance.en_US
dc.languageEN
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEvolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms.en_US
dc.typeJournal articleen_US
dc.creator.authorSøberg, Kristoffer
dc.creator.authorMoen, Line Victoria
dc.creator.authorSkålhegg, Bjørn Steen
dc.creator.authorLærdahl, Jon Kristen
cristin.unitcode185,51,12,0
cristin.unitnameAvdeling for molekylærmedisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1487113
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=12:e0181091&rft.spage=1&rft.date=2017
dc.identifier.jtitlePLoS ONE
dc.identifier.volume12:e0181091
dc.identifier.issue7
dc.identifier.startpage1
dc.identifier.endpage17
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0181091
dc.identifier.urnURN:NBN:no-67665
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/65136/2/journal.pone.0181091.pdf
dc.type.versionPublishedVersion


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