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The global brain health survey: Development of a multi-language survey of public views on brain health 
Ljøsne, Isabelle Sylvie Budin; Friedman, Barbara Bodorkos; Suri, Sana; Solé-Padullés, Cristina; Düzel, Sandra; Drevon, Christian A; Baaré, William F.C.; Mowinckel, Athanasia Monika; Zsoldos, Enikő; Madsen, Kathrine Skak; Carver, Rebecca Bruu; Ghisletta, Paolo; Arnesen, Mari; Bartrés Faz, David; Brandmaier, Andreas M.; Fjell, Anders Martin; Kvalbein, Aud; Henson, Richard N.; Kievit, Rogier A.; Nawijn, Laura; Pochet, Roland; Schnitzler, Alfons; Walhovd, Kristine B; Zasiekina, Larysa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Brain health is a multi-faceted concept used to describe brain physiology, cognitive function, mental health and well-being. Diseases of the brain account for one third of the global burden of disease and are ...
Self-reported sleep problems are related to amyloid deposition in cortical regions with high HOMER1 gene expression 
Fjell, Anders Martin; Sederevicius, Donatas; Sneve, Markus Handal; de Lange, Ann-Marie Glasø; Bråthen, Anne Cecilie Sjøli; Idland, Ane-Victoria; Watne, Leiv Otto; Wang, Yunpeng; Reinbold, Céline Sonja; Blennow, Kaj; Zetterberg, Henrik; Hong, S; Bertram, Lars; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Sleep problems are related to the elevated levels of the Alzheimer’s disease (AD) biomarker β-amyloid (Aβ). Hypotheses about the causes of this relationship can be generated from molecular markers of sleep problems identified ...
Biomarker Profiling Beyond Amyloid and Tau: Cerebrospinal Fluid Markers, Hippocampal Atrophy, and Memory Change in Cognitively Unimpaired Older Adults 
Idland, Ane-Victoria; Sala-Llonch, Roser; Watne, Leiv; Brækhus, Anne; Hansson, Oskar; Blennow, Kaj; Zetterberg, Henrik; Sørensen, Øystein; Walhovd, Kristine B; Wyller, Torgeir Bruun; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64-93 years) with different profiles of the cerebrospinal fluid ...
CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults 
Halaas, Nathalie Bodd; Henjum, Kristi; Blennow, Kaj; Dakhil, Shams; Idland, Ane-Victoria; Nilsson, Lars; Sederevicius, Donatas; Vidal-Piñeiro, Didac; Walhovd, Kristine B; Wyller, Torgeir Bruun; Zetterberg, Henrik; Watne, Leiv; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Neuroinflammation may be a key factor in brain atrophy in aging and age-related neurodegenerative disease. The objective of this study was to test the association between microglial expression of soluble Triggering Receptor ...
Age-Related Differences in Functional AsymmetryDuring Memory Retrieval Revisited: No Evidence forContralateral Overactivation or Compensation 
Roe, James Michael; Vidal-Piñeiro, Didac; Sneve, Markus Handal; Kompus, Kristiina; Greve, Douglas N.; Walhovd, Kristine B; Fjell, Anders Martin; Westerhausen, René (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Brain asymmetry is inherent to cognitive processing and seems to reflect processing efficiency. Lower frontal asymmetry is often observed in older adults during memory retrieval, yet it is unclear whether lower asymmetry ...
Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan 
Walhovd, Kristine B; Fjell, Anders Martin; Sørensen, Øystein; Mowinckel, Athanasia Monika; Reinbold, Céline Sonja; Idland, Ane-Victoria; Watne, Leiv Otto; Franke, Andre; Dobricic, Valerija; Kilpert, Fabian; Bertram, Lars; Wang, Yunpeng (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To test the hypothesis that genetic risk for Alzheimer disease (AD) may represent a stable influence on the brain from early in life, rather than being primarily age dependent, we investigated in a lifespan sample ...
The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan 
Vidal-Piñeiro, Didac; Sneve, Markus Handal; Amlien, Inge Kasbohm; Grydeland, Håkon; Mowinckel, Athanasia Monika; Roe, James Michael; Sørensen, Øystein; Nyberg, Lars; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract It has been suggested that specific forms of cognition in older age rely largely on late-life specific mechanisms. Here instead, we tested using task-fMRI (n = 540, age 6–82 years) whether the functional ...
Cellular correlates of cortical thinning throughout the lifespan 
Vidal-Piñeiro, Didac; Parker, Nadine; Shin, Jean; French, Leon; Grydeland, Håkon; Jackowski, Andrea; Mowinckel, Athanasia Monika; Patel, Yash; Pausova, Zdenka; salum, giovanni; Sørensen, Øystein; Walhovd, Kristine B; Paus, Tomáš; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology technique and gene ...
Meta-analysis of generalized additive models in neuroimaging studies 
Sørensen, Øystein; Brandmaier, Andreas M.; Macià, Dídac; Ebmeier, Klaus; Ghisletta, Paolo; Kievit, Rogier A.; Mowinckel, Athanasia Monika; Walhovd, Kristine B; Westerhausen, Rene; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Analyzing data from multiple neuroimaging studies has great potential in terms of increasing statistical power, enabling detection of effects of smaller magnitude than would be possible when analyzing each study separately ...
A recipe for accurate estimation of lifespan brain trajectories, distinguishing longitudinal and cohort effects 
Sørensen, Øystein; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We address the problem of estimating how different parts of the brain develop and change throughout the lifespan, and how these trajectories are affected by genetic and environmental factors. Estimation of these lifespan ...
Error processing in the adolescent brain: Age-related differences in electrophysiology, behavioral adaptation, and brain morphology 
Øverbye, Knut; Walhovd, Kristine B; Paus, Tomáš; Fjell, Anders Martin; Huster, Rene; Tamnes, Christian Krog (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Detecting errors and adjusting behaviour appropriately are fundamental cognitive abilities that are known to improve through adolescence. The cognitive and neural processes underlying this development, however, are still ...
Volumetric and microstructural regional changes of the hippocampus underlying development of recall performance after extended retention intervals 
Fjell, Anders Martin; Sneve, Markus Handal; Sederevicius, Donatas; Sørensen, Øystein; Krogsrud, Stine Kleppe; Mowinckel, Athanasia Monika; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Performance on recall tests improves through childhood and adolescence, in part due to structural maturation of the medial temporal cortex. Although partly different processes support successful recall over shorter vs. ...
Elaboration Benefits Source Memory Encoding Through Centrality Change 
Amlien, Inge Kasbohm; Sneve, Markus Handal; Vidal-Pineiro, Didac; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Variations in levels of processing affect memory encoding and subsequent retrieval performance, but it is unknown how processing depth affects communication patterns within the network of interconnected brain regions ...
Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium 
Fjell, Anders Martin; Sørensen, Øystein; Amlien, Inge Kasbohm; Bartrés-Faz, David; Bros, Didac Macia; Buchmann, Nikolaus; Demuth, Ilja; Drevon, Christian A.; duzel, Sandra; Ebmeier, K P; Idland, Ane-Victoria; Kietzmann, Tim C; Kievit, Rogier; Kühn, Simone; Lindenberger, Ulman; Mowinckel, Athanasia Monika; Nyberg, Lars Erik; Price, Darren; Sexton, Claire; Sole-Padulles, Cristina; Pudas, Sara; Sederevicius, Donatas; Suri, Sana; Wagner, Gerd; Watne, Leiv Otto; Westerhausen, René; Zsoldos, Eniko; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Objectives Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal ...
Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium 
Friedman, Barbara Bodorkos; Suri, Sana; Sole-Padulles, Cristina; Düzel, Sandra; Drevon, Christian A; Baaré, William F. C.; Bartrés-Faz, David; Fjell, Anders Martin; Johansen-Berg, Heidi; Madsen, Kathrine S.; Nyberg, Lars; Penninx, Brenda W.J.H.; Sexton, Claire; Walhovd, Kristine B; Zsoldos, Enikő; Ljøsne, Isabelle Sylvie Budin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background and Objectives A healthy brain is central to physical and mental well-being. In this multi-site, qualitative study, we investigated views and attitudes of adult participants in brain research ...
Prosocial behavior relates to the rate and timing of cortical thinning from adolescence to young adulthood 
Ferschmann, Lia; Vijayakumar, Nandita; Grydeland, Håkon; Øverbye, Knut; Sederevicius, Donatas; Due-Tønnessen, Paulina; Fjell, Anders Martin; Walhovd, Kristine B; Tamnes, Christian Krog (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Prosocial behavior, or voluntary actions that intentionally benefit others, relate to desirable developmental outcomes such as peer acceptance, while lack of prosocial behavior has been associated with several neurodevelopmental ...
Mental health in youth prenatally exposed to opioids and poly-drugs and raised in permanent foster/adoptive homes: A prospective longitudinal study 
Nygaard, Egil; Slinning, Kari; Moe, Vibeke; Fjell, Anders Martin; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Abstract Background Little is known about the mental health of prenatally opioid- and polydrug-exposed youth raised in foster/adoptive families. Aim To compare mental health problems among two groups of youth, one prenatally ...
Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan 
Parker, Nadine; Vidal-Piñeiro, Didac; French, Leon; Shin, Jean; Adams, Hieab H.; Brodaty, Henry; Cox, Simon R; Deary, Ian; Fjell, Anders Martin; Frenzel, Stefan; Grabe, Hans; Hosten, Norbert; Ikram, Mohammad A.; jiang, jiyang; Knol, Maria J.; Mazoyer, Bernard; Mishra, Aniket; Sachdev, Perminder; salum, giovanni; Satizabal, Claudia L; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Schumann, Gunter; Volzke, Henry; Walhovd, Kristine B; Wen, Wei; Wittfeld, Katharina; Yang, Qiong; debette, stephanie; Pausova, Zdenka; Paus, Tomáš (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Exposures to life stressors accumulate across the lifespan, with possible impact on brain health. Little is known, however, about the mechanisms mediating age-related changes in brain structure. We use a lifespan sample ...
Structural variability in the human brain reflects fine-grained functional architecture at the population level 
Smith, Steve; Duff, Eugene; Groves, Adrian; Nichols, Thomas E.; Jbabdi, Saad; Westlye, Lars Tjelta; Tamnes, Christian Krog; Engvig, Andreas; Walhovd, Kristine B; Fjell, Anders Martin; Johansen-Berg, Heidi; Douaud, Gwenaëlle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Human brain structure topography is thought to be related in part to functional specialization. However, the extent of such relationships is unclear. Here, using a data-driven, multimodal approach for studying brain structure ...
A longitudinal study of computerized cognitive training in stroke patients - effects on cognitive function and white matter 
Nyberg, Claudia Kim; Nordvik, Jan Egil; Becker, Frank; Rohani, Darius; Sederevicius, Donatas; Fjell, Anders Martin; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Background Computerized cognitive training is suggested to enhance attention and working memory functioning following stroke, but effects on brain and behavior are not sufficiently studied and longitudinal studies assessing ...
Multimodal cortical and hippocampal prediction of episodic‐memory plasticity in young and older adults 
Bråthen, Anne Cecilie Sjøli; de Lange, Ann-Marie Glasø; Rohani, Darius; Sneve, Markus Handal; Fjell, Anders Martin; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Episodic memory can be trained in both early and late adulthood, but there is considerable variation in cognitive improvement across individuals. Which brain characteristics make some individuals benefit more than others? ...
Neuroanatomical characteristics of youths with prenatal opioid and poly-drug exposure 
Nygaard, Egil; Slinning, Kari; Moe, Vibeke; Due-Tønnessen, Paulina; Fjell, Anders Martin; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Neuroanatomical and cognitive differences have been documented during childhood between children with prenatal opioid- and poly-drug exposure and controls in small samples. We investigated whether these differences persisted ...
The Temporal Dynamics of Brain Plasticity in Aging 
de Lange, Ann-Marie Glasø; Bråthen, Anne Cecilie Sjøli; Rohani, Darius; Fjell, Anders Martin; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Cognitive training has been suggested as a possible remediation of decline in brain structure with older age. However, it is unknown whether training effects are transient or enduring, as no studies have examined ...
High-expanding regions in primate cortical brain evolution support supramodal cognitive flexibility 
Sneve, Markus Handal; Grydeland, Håkon; Rosa, Marcello G P; Paus, Tomáš; Chaplin, Tristan; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Development and decline of the hippocampal long-axis specialization and differentiation during encoding and retrieval of episodic memories 
Langnes, Espen; Vidal-Piñeiro, Didac; Sneve, Markus Handal; Amlien, Inge Kasbohm; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Maintained Frontal Activity Underlies High Memory Function Over 8 Years in Aging 
Vidal-Piñeiro, Didac; Sneve, Markus Handal; Nyberg, Lars; Mowinckel, Athanasia Monika; Sederevicius, Donatas; Walhovd, K.B.; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Continuity and discontinuity in human cortical development and change from embryonic stages to old age 
Fjell, Anders Martin; Chen, Chi-Hua Chen; Sederevicius, Donatas; Sneve, Markus Handal; Grydeland, Håkon; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Ferschmann, Lia; Ness, Hedda; Folvik, Line; Beck, Dani; Mowinckel, Athanasia Monika; Tamnes, Christian Krog; Westerhausen, René; Håberg, Asta; Dale, Anders M; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Parallel but independent reduction of emotional awareness and corpus callosum connectivity in older age 
Skumlien, M.; Sederevicius, Donatas; Fjell, Anders Martin; Walhovd, Kristine B; Westerhausen, Rene (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Differential functional specialization of the left and right hemispheres for linguistic and emotional functions, respectively, suggest that interhemispheric communication via the corpus callosum is critical for emotional ...
Waves of Maturation and Senescence in Microstructural MRI Markers of Human Cortical Myelination over the Lifespan 
Grydeland, Håkon; Vértes, Petra; Váša, František; Romero-Garcia, Rafael; Whitaker, Kirstie; Aaron F., Alexander-Bloch; Bjørnerud, Atle; Patel, Ameera X.; Sederevicius, Donatas; Tamnes, Christian Krog; Westlye, Lars Tjelta; White, Simon; Walhovd, Kristine B; Fjell, Anders Martin; Bullmore, Edward T. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Seminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to ...
Personality Traits Are Associated With Cortical Development Across Adolescence: A Longitudinal Structural MRI Study 
Ferschmann, Lia; Fjell, Anders Martin; Vollrath, Margarete E.; Grydeland, Håkon; Walhovd, Kristine B; Tamnes, Christian Krog (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
How personality traits relate to structural brain changes in development is an important but understudied question. In this study, cortical thickness (CT) and surface area (SA), estimated using magnetic resonance imaging ...
Social perspective taking is associated with self-reported prosocial behavior and regional cortical thickness across adolescence 
Tamnes, Christian Krog; Øverbye, Knut; Ferschmann, Lia; Fjell, Anders Martin; Walhovd, Kristine B; Blakemore, Sarah-Jayne; Dumontheil, Iroise (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Basic perspective taking and mentalizing abilities develop in childhood, but recent studies indicate that the use of social perspective taking to guide decisions and actions has a prolonged development that continues ...
Development of white matter microstructure in relation to verbal and visuospatial working memory - A longitudinal study 
Krogsrud, Stine Kleppe; Fjell, Anders Martin; Tamnes, Christian Krog; Grydeland, Håkon; Due-Tønnessen, Paulina; Bjørnerud, Atle; Sampaio-Baptista, Cassandra; Andersson, Jesper; Johansen-Berg, Heidi; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Working memory capacity is pivotal for a broad specter of cognitive tasks and develops throughout childhood. This must in part rely on development of neural connections and white matter microstructure maturation, but there ...
The lifespan trajectory of the encoding-retrieval flip: A multimodal examination of medial parietal cortex contributions to episodic memory 
Amlien, Inge Kasbohm; Sneve, Markus Handal; Vidal-Piñeiro, Didac; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The formation of episodic memories is associated with deactivation during encoding and activation during retrieval in the posteromedial cortex (PMC). We hypothesized that the encoding/retrieval (E/R) flip is a critical ...
The Effects of Memory Training on Behavioral and Microstructural Plasticity in Young and Older Adults 
de Lange, Ann-Marie Glasø; Bråthen, Anne Cecilie Sjøli; Rohani, Darius; Grydeland, Håkon; Fjell, Anders Martin; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / SubmittedVersion; Peer reviewed, 2017)
Age differences in human brain plasticity are assumed, but have not been systematically investigated. In this longitudinal study, we investigated changes in white matter (WM) microstructure in response to memory training ...
Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain") 
Walhovd, Kristine B; Fjell, Anders Martin; Westerhausen, René; Nyberg, L; Ebmeier, K P; Lindenberger, U; Bartres-Faz, D; Baare, W F C; Siebner, H R; Henson, R; Drevon, C A; Knudsen, Gun Peggy S.; Ljøsne, Isabelle Budin; Penninx, B W J H; Ghisletta, P; Rogeberg, O; Tyler, L; Bertram, L (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Themainobjective of "Lifebrain" is toidentify thedeterminantsofbrain, cognitive andmental(BCM)health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the ...
CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults 
Idland, Ane-Victoria; Roser, Sala-Llonch; Borza, Tom; Watne, Leiv Otto; Wyller, Torgeir Bruun; Brækhus, Anne; Zetterberg, Henrik; Blennow, Kaj; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established ...
Neural correlates of durable memories across the adult lifespan: brain activity at encoding and retrieval 
Vidal-Piñeiro, Didac; Sneve, Markus Handal; Storsve, Andreas Berg; Roe, James Michael; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AccpetedVersion; Peer reviewed, 2017)
Relationship between structural and functional connectivity change across the lifespan – a longitudinal investigation 
Fjell, Anders Martin; Sneve, Markus Handal; Grydeland, Håkon; Storsve, Andreas Berg; Amlien, Inge Kasbohm; Yendiki, Anastasia; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity ...
Longitudinal changes in white matter tract integrity across the adult lifespan and its relation to cortical thinning 
Storsve, Andreas Berg; Fjell, Anders Martin; Yendiki, Anastasia; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
A causal link between decreases in white matter (WM) integrity and cortical degeneration is assumed, but there is scarce knowledge on the relationship between these changes across the adult human lifespan. We investigated ...
The Disconnected Brain and Executive Function Decline in Aging 
Fjell, Anders Martin; Sneve, Markus Handal; Grydeland, Håkon; Storsve, Andreas Berg; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Higher order speeded cognitive abilities depend on efficient coordination of activity across the brain, rendering them vulnerable to age reductions in structural and functional brain connectivity. The concept of “disconnected ...
Accelerated longitudinal gray/white matter contrast decline in aging in lightly myelinated cortical regions 
Piñeiro, Didac Vidal; Walhovd, Kristine B; Storsve, Andreas Berg; Grydeland, Håkon; Rohani, Darius Adam; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Highly myelinated cortical regions seem to develop early and are more robust to age-related decline. By use of different magnetic resonance imaging (MRI) measures such as contrast between T1- and T2-weighted MRI scans ...
Decoupling of large-scale brain networks supports the consolidation of durable episodic memories 
Sneve, Markus Handal; Grydeland, Håkon; Amlien, Inge Kasbohm; Langnes, Espen; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
At a large scale, the human brain is organized into modules of interconnected regions, some of which play opposing roles in supporting cognition. In particular, the Default-Mode Network (DMN) has been linked to operations ...
Through thick and thin: A need to reconcile contradictory results on trajectories in human cortical development 
Walhovd, Kristine B; Fjell, Anders Martin; Giedd, J; Dale, AM; Brown, Timothy T. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Understanding how brain development normally proceeds is a premise of understanding neurodevelopmental disorders. This has sparked a wealth of magnetic resonance imaging (MRI) studies. Unfortunately, they are in marked ...
Mechanisms underlying encoding of short-lived versus durable episodic memories 
Sneve, Markus Handal; Grydeland, Håkon; Nyberg, Lars; Bowles, Ben; Amlien, Inge K; Langnes, Espen; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
We continuously encounter and process novel events in the surrounding world, but only some episodes will leave detailed memory traces that can be recollected after weeks and months. Here, our aim was to monitor brain ...
A longitudinal study of disability, cognition and gray matter atrophy in early multiple sclerosis patients according to evidence of disease activity 
Nygaard, Gro Owren; Celius, Elisabeth Gulowsen; de Rodez Benavent, Sigrid Aune; Sowa, Piotr; Gustavsen, Marte Wendel; Fjell, Anders Martin; Landrø, Nils Inge; Walhovd, Kristine B; Harbo, Hanne Flinstad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
New treatment options may make “no evidence of disease activity” (NEDA: no relapses or disability progression and no new/enlarging MRI lesions, as opposed to “evidence of disease activity” (EDA) with at least one of the ...
High-expanding cortical regions in human development and evolution are related to higher intellectual abilities 
Fjell, Anders Martin; Westlye, Lars Tjelta; Amlien, Inge; Tamnes, Christian Krog; Grydeland, Håkon; Engvig, Andreas; Espeseth, Thomas; Reinvang, Ivar; Lundervold, Astri; Lundervold, Arvid; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Cortical surface area has tremendously expanded during human evolution, and similar patterns of cortical expansion have been observed during childhood development. An intriguing hypothesis is that the high-expanding cortical ...
The Roots of Alzheimer’s Disease: Are High-Expanding Cortical Areas Preferentially Targeted? 
Fjell, Anders Martin; Amlien, Inge; Sneve, Markus Handal; Grydeland, Håkon; Tamnes, Christian Krog; Chaplin, Tristan; Rosa, Marcello; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Alzheimer's disease (AD) is regarded a human-specific condition, and it has been suggested that brain regions highly expanded in humans compared with other primates are selectively targeted. We calculated shared and unique ...
Intracortical Posterior Cingulate Myelin Content Relates to Error Processing – Results From T1- and T2-weighted MRI Myelin Mapping and Electrophysiology in Healthy Adults 
Grydeland, Håkon; Westlye, Lars Tjelta; Walhovd, Kristine B; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Myelin content of the cerebral cortex likely impacts cognitive functioning, but this notion has scarcely been investigated in vivo in humans. Here we tested for a relationship between intracortical myelin and a direct ...
Premises of plasticity – and the loneliness of the medial temporal lobe 
Walhovd, Kristine B; Westerhausen, Rene; de Lange, Ann-Marie Glasø; Bråthen, Anne Cecilie Sjøli; Grydeland, Håkon; Engvig, Andreas; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
In this perspective paper, we examine possible premises of plasticity in the neural substrates underlying cognitive change. We take the special role of the medial temporal lobe as an anchoring point, but also investigate ...
Development and aging of cortical thickness correspond to genetic organization patterns 
Fjell, Anders Martin; Grydeland, Håkon; Krogsrud, Stine Kleppe; Amlien, Inge Kasbohm; Rohani, Darius Adam; Ferschmann, Lia; Storsve, Andreas Berg; Tamnes, Christian Krog; Sala Llonch, Roser; Due-Tønnessen, Paulina; Bjørnerud, Atle; Sølsnes, Anne Elisabeth; Håberg, Asta; Skranes, Jon Sverre; Bartsch, Hauke; Chen, Chi-Hua; Thompson, Wesley K.; Panizzon, Matthew S.; Kremen, William S.; Dale, Anders M.; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
There is a growing realization that early life influences have lasting impact on brain function and structure. Recent research has demon- strated that genetic relationships in adults can be used to parcellate the cortex ...
Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging 
Fjell, Anders Martin; Sneve, Markus Handal; Grydeland, Håkon; Storsve, Andreas Berg; de Lange, Ann-Marie Glasø; Amlien, Inge Kasbohm; Røgeberg, Ole; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
A major task of contemporary cognitive neuroscience of aging is to explain why episodic memory declines. Change in resting-state functional connectivity (rsFC) could be a mechanism accounting for reduced function. We ...
Brain events underlying episodic memory changes in aging: A longitudinal investigation of structural and functional connectivity 
Fjell, Anders Martin; Sneve, Markus Handal; Storsve, Andreas Berg; Grydeland, Håkon; Yendiki, Anastasia; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Episodic memories are established and maintained by close interplay between hippocampus and other cortical regions, but degradation of a fronto-striatal network has been suggested to be a driving force of memory decline ...
Brain structural maturation and the foundations of cognitive behavioral development 
Walhovd, Kristine B; Tamnes, Christian Krog; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Purpose of review: Thorough knowledge of normal neural foundations for cognitive behavioral development is fundamental to understand the mechanisms of both neurodevelopmental disorders and normal adaptation. This review ...
Regional hippocampal volumes and development predict learning and memory 
Tamnes, Christian Krog; Walhovd, Kristine B; Engvig, Andreas; Grydeland, Håkon; Krogsrud, Stine Kleppe; Østby, Ylva; Holland, Dominic; Dale, Anders; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
The hippocampus is an anatomically and functionally heterogeneous structure, but longitudinal studies of its regional development are scarce and it is not known whether protracted maturation of the hippocampus in adolescence ...
Development of hippocampal subfield volumes from 4 to 22 years 
Krogsrud, Stine Kleppe; Tamnes, Christian Krog; Fjell, Anders Martin; Amlien, Inge; Grydeland, Håkon; Sulutvedt, Unni; Due-Tønnessen, Paulina; Bjørnerud, Atle; Sølsnes, Anne Elisabeth; Håberg, Asta; Skranes, Jon Sverre; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
The hippocampus supports several important cognitive functions known to undergo substantial development during childhood and adolescence, for example, encoding and consolidation of vivid personal memories. However, diverging ...
Differential longitudinal changes in cortical thickness, surface area and volume across the adult lifespan: Regions of accelerating and decelerating change 
Storsve, Andreas Berg; Fjell, Anders Martin; Tamnes, Christian Krog; Westlye, Lars Tjelta; Øverbye, Knut; Aasland, Hilde Wiede; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Human cortical thickness and surface area are genetically independent, emerge through different neurobiological events during development, and are sensitive to different clinical conditions. However, the relationship between ...
What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus 
Fjell, Anders Martin; McEvoy, Linda; Holland, Dominic; Dale, Anders; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
What can be expected in normal aging, and where does normal aging stop and pathological neurodegeneration begin? With the slow progression of age-related dementias such as Alzheimer's disease (AD), it is difficult to ...
Cognitive decline and brain pathology in aging - need for a dimensional, lifespan and systems vulnerability view 
Walhovd, Kristine B; Fjell, Anders Martin; Espeseth, Thomas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Changes in brain structure and activity as well as cognitive function are commonly seen in aging. However, it is not known when aging of brain and cognition starts, and how much of the changes observed in seemingly healthy ...
Effects of Cognitive Training on Gray Matter Volumes in Memory Clinic Patients with Subjective Memory Impairment 
Engvig, Andreas; Fjell, Anders Martin; Westlye, Lars Tjelta; Skaane, Nina Voss; Dale, Anders M.; Holland, Dominic; Due-Tønnessen, Paulina; Sundset, Øyvind; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Subjective memory impairment (SMI) is a common risk factor for Alzheimer's disease, with few established options for treatment. Here we investigate the effects of two months episodic memory training on regional brain atrophy ...
Performance monitoring in children and adolescents: A review of developmental changes in the error-related negativity and brain maturation 
Tamnes, Christian Krog; Walhovd, Kristine B; Torstveit, Mari; Sells, Victoria Torp; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2013)
To realize our goals we continuously adapt our behavior according to internal or external feedback. Errors provide an important source for such feedback and elicit a scalp electrical potential referred to as the error-related ...
Critical ages in the life course of the adult brain: nonlinear subcortical aging 
Fjell, Anders Martin; Westlye, Lars Tjelta; Grydeland, Håkon; Amlien, Inge; Espeseth, Thomas; Reinvang, Ivar; Raz, Naftali; Holland, Dominic; Dale, Anders; Walhovd, Kristine B (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2013)
Age-related changes in brain structure result from a complex interplay among various neurobiological processes, which may contribute to more complex trajectories than what can be described by simple linear or quadratic ...
Longitudinal Working Memory Development Is Related to Structural Maturation of Frontal and Parietal Cortices 
Tamnes, Christian Krog; Walhovd, Kristine B; Grydeland, Håkon; Holland, Dominic; Østby, Ylva; Dale, Anders M.; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Parallels between patterns of brain maturation and cognitive development have been observed repeatedly, but studies directly testing the relationships between improvements in specific cognitive functions and structural ...
Intracortical Myelin Links with Performance Variability across the Human Lifespan: Results from T1-and T2-Weighted MRI Myelin Mapping and Diffusion Tensor Imaging 
Grydeland, Håkon; Walhovd, Kristine B; Tamnes, Christian Krog; Westlye, Lars Tjelta; Fjell, Anders Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Cerebral myelin maturation and aging-related degradation constitute fundamental features of human brain integrity and functioning. Although mostly studied in the white matter, the cerebral cortex contains significant amounts ...
 
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