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Now showing items 1-32 of 32
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
To investigate whether changes in serum lipids are associated with cognitive performance in first episode psychosis (FEP) patients during their first year of antipsychotic drug treatment. One hundred and thirty-two ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Schizophrenia (SCZ) is associated with an increased risk of violence compared to the general population. Previous studies have indicated smaller hippocampal and amygdala volumes in violent than non-violent psychotic patients. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The deviation between chronological age and age predicted using brain MRI is a putative marker of overall brain health. Age prediction based on structural MRI data shows high accuracy in common brain disorders. However, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cognitive impairments are considered core features in schizophrenia and other psychotic disorders. Cognitive impairments are, to a lesser degree, also documented in healthy first-degree relatives. Although recent studies ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ...
Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective: Individuals exposed to childhood trauma display longstanding modifications of the Hypothalamic–Pituitary–Adrenal (HPA) axis, as well as cognitive impairments. Schizophrenia spectrum disorder (SZ) and bipolar ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Lack of clinical insight in patients with schizophrenia is an obstacle to optimal treatment. Social cognition is one of several variables central to insight deficits in schizophrenia. The aim of this study was to investigate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of ...
Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
The prevalence of obesity, metabolic syndrome and type 2 diabetes mellitus is increased among patients with severe mental disorders, and particularly use of second generation antipsychotic drugs is associated ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Schizophrenia is characterized by social cognitive impairments that predict functioning. Social cognitive training aims to target these impairments. Although it can improve the targeted social cognitive domain, it is unclear ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Reduced telomere length (TL) and structural brain abnormalities have been reported in patients with schizophrenia (SZ) and bipolar disorder (BD). Childhood traumatic events are more frequent in SZ and BD than in healthy ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Aims/hypothesis
MODY can be wrongly diagnosed as type 1 diabetes in children. We aimed to find the prevalence of MODY in a nationwide population-based registry of childhood diabetes.
Methods
Using next-generation ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic correlation has been reported ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives
Perceived/experienced stigma and its relationship with clinical outcome were investigated across the first year of treatment in a large sample with first-episode psychosis (FEP).
Methods
FEP participants ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Objectives: Knowledge about self-rated disability over time in psychotic disorders is limited. How self-rateddisability relates to clinician-rated global functioning, self-rated life satisfaction and symptomatology ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Aim: To investigate the relationship between anomalous self-experiences and duration of untreated psychosis in a sample of patients with first episode schizophrenia spectrum disorders.
Methods: Anomalous self-experiences ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spectrum. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Schizophrenia (SZ) is a psychotic disorder with significant cognitive dysfunction. Abnormal brain activation during cognitive processing has been reported, both in task-positive and task-negative networks. Further, structural ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Objectives Bipolar disorder (BD) is a highly heritable disorder with polygenic inheritance. Among the most consistent findings from functional magnetic imaging (fMRI) studies are limbic hyperactivation and dorsal hypoactivation. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Data suggest that individuals with schizophrenia (SZ) and superior intelligence can present without specific neurocognitive deficits. However, neurocognitive decrements, defined as worse cognition than expected, have been ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of genetic ...