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Now showing items 1-86 of 86
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Concentrations of pro-inflammatory cytokines –interleukin-6 (IL-6) and interleukin-8 (IL-8) – are increased with age and in Alzheimer’s disease (AD). It is not clear whether concentrations of IL-6 and IL-8 in the central ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been linked to age-related neurodegeneration and Alzheimer’s disease (AD), but their role in normal aging is poorly understood. We used linear mixed ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background
Lifestyle-related risk factors, such as obesity, physical inactivity, short sleep, smoking and alcohol use, have been associated with low hippocampal and total grey matter volumes (GMV). However, these risk ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Abstract Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Objective: The Delis-Kaplan Executive Function System (D-KEFS) Color-Word-Interference Test (CWIT; AKA Stroop test) is a widely used measure of processing speed and executive function. While test materials and instructions ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Many sleep less than recommended without experiencing daytime sleepiness. According to prevailing views, short sleep increases risk of lower brain health and cognitive function. Chronic mild sleep deprivation could cause ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract
Higher socio-economic status (SES) has been proposed to have facilitating and protective effects on brain and cognition. We ask whether relationships between SES, brain volumes and cognitive ability ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract
It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Background Loneliness is most prevalent during adolescence and late life and has been associated with mental health disorders as well as with cognitive decline during aging. Associations between longitudinal measures of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Objectives To investigate public perspectives on brain health. Design Cross-sectional multilanguage online survey. Setting Lifebrain posted the survey on its website and social media and shared it with stakeholders. The ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Risk and protective factors for cognitive function in aging may affect how much individuals benefit from their environment or life experiences by preserving or improving cognitive abilities. We investigated the relations ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Emotional disorders commonly emerge in adolescence, a period characterized by changes in emotion-related processes. Thus, the ability to regulate emotions is crucial for well-being and adaptive social functioning during ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Cognitive control enables goal-oriented adaptation to a fast-changing environment and has a protracted development spanning into young adulthood. The neurocognitive processes underlying this development are poorly understood. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Human cognitive development is manifold, with different functions developing at different speeds at different ages. Attention is an important domain of this cognitive development, and involves distinct developmental ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background To test the hypothesis that worse self-reported sleep relates to memory decay and reduced hippocampal integrity as indexed by increased intra-hippocampal water diffusion, and that the relations are stronger in ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Brain age is a widely used index for quantifying individuals’ brain health as deviation from a normative brain aging trajectory. Higher-than-expected brain age is thought partially to reflect above-average rate of brain ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Brain health is a multi-faceted concept used to describe brain physiology, cognitive function, mental health and well-being. Diseases of the brain account for one third of the global burden of disease and are ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Analyzing data from multiple neuroimaging studies has great potential in terms of increasing statistical power, enabling detection of effects of smaller magnitude than would be possible when analyzing each study separately ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We address the problem of estimating how different parts of the brain develop and change throughout the lifespan, and how these trajectories are affected by genetic and environmental factors. Estimation of these lifespan ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology technique and gene ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
It has been suggested that specific forms of cognition in older age rely largely on late-life specific mechanisms. Here instead, we tested using task-fMRI (n = 540, age 6–82 years) whether the functional ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Memory performance results from plasticity, the ability to change with experience. We show that benefit from practice over a few trials, learning slope, is predictive of long-term recall and hippocampal volume across a ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Background and purpose: Although methylphenidate is frequently used to treat children with attention-deficit/hyperactivity disorder, it is currently unknown how methylphenidate affects brain development. In a ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
There is evidence for a hippocampal long axis anterior–posterior (AP) differentiation in memory processing, which may have implications for the changes in episodic memory performance seen across development and aging. The ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Sleep problems are related to the elevated levels of the Alzheimer’s disease (AD) biomarker β-amyloid (Aβ). Hypotheses about the causes of this relationship can be generated from molecular markers of sleep problems identified ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Brain asymmetry is inherent to cognitive processing and seems to reflect processing efficiency. Lower frontal asymmetry is often observed in older adults during memory retrieval, yet it is unclear whether lower asymmetry ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Neuroinflammation may be a key factor in brain atrophy in aging and age-related neurodegenerative disease. The objective of this study was to test the association between microglial expression of soluble Triggering Receptor ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64-93 years) with different profiles of the cerebrospinal fluid ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To test the hypothesis that genetic risk for Alzheimer disease (AD) may represent a stable influence on the brain from early in life, rather than being primarily age dependent, we investigated in a lifespan sample ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Abstract Background Little is known about the mental health of prenatally opioid- and polydrug-exposed youth raised in foster/adoptive families. Aim To compare mental health problems among two groups of youth, one prenatally ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Objectives
Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background and Objectives
A healthy brain is central to physical and mental well-being. In this multi-site, qualitative study, we investigated views and attitudes of adult participants in brain research ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Prosocial behavior, or voluntary actions that intentionally benefit others, relate to desirable developmental outcomes such as peer acceptance, while lack of prosocial behavior has been associated with several neurodevelopmental ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Performance on recall tests improves through childhood and adolescence, in part due to structural maturation of the medial temporal cortex. Although partly different processes support successful recall over shorter vs. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Variations in levels of processing affect memory encoding and subsequent retrieval performance, but it is unknown how processing depth affects communication patterns within the network of interconnected brain regions ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Exposures to life stressors accumulate across the lifespan, with possible impact on brain health. Little is known, however, about the mechanisms mediating age-related changes in brain structure. We use a lifespan sample ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Human brain structure topography is thought to be related in part to functional specialization. However, the extent of such relationships is unclear. Here, using a data-driven, multimodal approach for studying brain structure ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Detecting errors and adjusting behaviour appropriately are fundamental cognitive abilities that are known to improve through adolescence. The cognitive and neural processes underlying this development, however, are still ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Differential functional specialization of the left and right hemispheres for linguistic and emotional functions, respectively, suggest that interhemispheric communication via the corpus callosum is critical for emotional ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Seminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Background Computerized cognitive training is suggested to enhance attention and working memory functioning following stroke, but effects on brain and behavior are not sufficiently studied and longitudinal studies assessing ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Intellectual abilities are supported by a large-scale fronto-parietal brain network distributed across both cerebral hemispheres. This bihemispheric network suggests a functional relevance of inter-hemispheric coordination, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Cognitive training has been suggested as a possible remediation of decline in brain structure with older age. However, it is unknown whether training effects are transient or enduring, as no studies have examined ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Episodic memory can be trained in both early and late adulthood, but there is considerable variation in cognitive improvement across individuals. Which brain characteristics make some individuals benefit more than others? ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Neuroanatomical and cognitive differences have been documented during childhood between children with prenatal opioid- and poly-drug exposure and controls in small samples. We investigated whether these differences persisted ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The formation of episodic memories is associated with deactivation during encoding and activation during retrieval in the posteromedial cortex (PMC). We hypothesized that the encoding/retrieval (E/R) flip is a critical ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Basic perspective taking and mentalizing abilities develop in childhood, but recent studies indicate that the use of social perspective taking to guide decisions and actions has a prolonged development that continues ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
How personality traits relate to structural brain changes in development is an important but understudied question. In this study, cortical thickness (CT) and surface area (SA), estimated using magnetic resonance imaging ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Working memory capacity is pivotal for a broad specter of cognitive tasks and develops throughout childhood. This must in part rely on development of neural connections and white matter microstructure maturation, but there ...
(Journal article / Tidsskriftartikkel / SubmittedVersion; Peer reviewed, 2017)
Age differences in human brain plasticity are assumed, but have not been systematically investigated. In this longitudinal study, we investigated changes in white matter (WM) microstructure in response to memory training ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established ...
(Journal article / Tidsskriftartikkel / AccpetedVersion; Peer reviewed, 2017)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Themainobjective of "Lifebrain" is toidentify thedeterminantsofbrain, cognitive andmental(BCM)health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
A causal link between decreases in white matter (WM) integrity and cortical degeneration is assumed, but there is scarce knowledge on the relationship between these changes across the adult human lifespan. We investigated ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Higher order speeded cognitive abilities depend on efficient coordination of activity across the brain, rendering them vulnerable to age reductions in structural and functional brain connectivity. The concept of “disconnected ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
At a large scale, the human brain is organized into modules of interconnected regions, some of which play opposing roles in supporting cognition. In particular, the Default-Mode Network (DMN) has been linked to operations ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Understanding how brain development normally proceeds is a premise of understanding neurodevelopmental disorders. This has sparked a wealth of magnetic resonance imaging (MRI) studies. Unfortunately, they are in marked ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Highly myelinated cortical regions seem to develop early and are more robust to age-related decline. By use of different magnetic resonance imaging (MRI) measures such as contrast between T1- and T2-weighted MRI scans ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
We continuously encounter and process novel events in the surrounding world, but only some episodes will leave detailed memory traces that can be recollected after weeks and months. Here, our aim was to monitor brain ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
New treatment options may make “no evidence of disease activity” (NEDA: no relapses or disability progression and no new/enlarging MRI lesions, as opposed to “evidence of disease activity” (EDA) with at least one of the ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Alzheimer's disease (AD) is regarded a human-specific condition, and it has been suggested that brain regions highly expanded in humans compared with other primates are selectively targeted. We calculated shared and unique ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Myelin content of the cerebral cortex likely impacts cognitive functioning, but this notion has scarcely been investigated in vivo in humans. Here we tested for a relationship between intracortical myelin and a direct ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
In this perspective paper, we examine possible premises of plasticity in the neural substrates underlying cognitive change. We take the special role of the medial temporal lobe as an anchoring point, but also investigate ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Cortical surface area has tremendously expanded during human evolution, and similar patterns of cortical expansion have been observed during childhood development. An intriguing hypothesis is that the high-expanding cortical ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
There is a growing realization that early life influences have lasting impact on brain function and structure. Recent research has demon- strated that genetic relationships in adults can be used to parcellate the cortex ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
A major task of contemporary cognitive neuroscience of aging is to explain why episodic memory declines. Change in resting-state functional connectivity (rsFC) could be a mechanism accounting for reduced function. We ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
Episodic memories are established and maintained by close interplay between hippocampus and other cortical regions, but degradation of a fronto-striatal network has been suggested to be a driving force of memory decline ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Purpose of review: Thorough knowledge of normal neural foundations for cognitive behavioral development is fundamental to understand the mechanisms of both neurodevelopmental disorders and normal adaptation. This review ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Changes in brain structure and activity as well as cognitive function are commonly seen in aging. However, it is not known when aging of brain and cognition starts, and how much of the changes observed in seemingly healthy ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
The hippocampus is an anatomically and functionally heterogeneous structure, but longitudinal studies of its regional development are scarce and it is not known whether protracted maturation of the hippocampus in adolescence ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
The hippocampus supports several important cognitive functions known to undergo substantial development during childhood and adolescence, for example, encoding and consolidation of vivid personal memories. However, diverging ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Human cortical thickness and surface area are genetically independent, emerge through different neurobiological events during development, and are sensitive to different clinical conditions. However, the relationship between ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
What can be expected in normal aging, and where does normal aging stop and pathological neurodegeneration begin? With the slow progression of age-related dementias such as Alzheimer's disease (AD), it is difficult to ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
Subjective memory impairment (SMI) is a common risk factor for Alzheimer's disease, with few established options for treatment. Here we investigate the effects of two months episodic memory training on regional brain atrophy ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2013)
To realize our goals we continuously adapt our behavior according to internal or external feedback. Errors provide an important source for such feedback and elicit a scalp electrical potential referred to as the error-related ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2013)
Age-related changes in brain structure result from a complex interplay among various neurobiological processes, which may contribute to more complex trajectories than what can be described by simple linear or quadratic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Parallels between patterns of brain maturation and cognitive development have been observed repeatedly, but studies directly testing the relationships between improvements in specific cognitive functions and structural ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Cerebral myelin maturation and aging-related degradation constitute fundamental features of human brain integrity and functioning. Although mostly studied in the white matter, the cerebral cortex contains significant amounts ...