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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Sleep problems are related to the elevated levels of the Alzheimer’s disease (AD) biomarker β-amyloid (Aβ). Hypotheses about the causes of this relationship can be generated from molecular markers of sleep problems identified ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Objectives
Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Neuroinflammation may be a key factor in brain atrophy in aging and age-related neurodegenerative disease. The objective of this study was to test the association between microglial expression of soluble Triggering Receptor ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64-93 years) with different profiles of the cerebrospinal fluid ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To test the hypothesis that genetic risk for Alzheimer disease (AD) may represent a stable influence on the brain from early in life, rather than being primarily age dependent, we investigated in a lifespan sample ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background: Delirium is associated with dementia and thus biomarkers reflecting neurodegeneration are of interest. Fatty acid-binding protein 3 (FABP3) is a cytoplasmic neuronal protein that has been isolated from the ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury. Methods: ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ...