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dc.date.accessioned2018-09-25T10:35:25Z
dc.date.available2018-09-25T10:35:25Z
dc.date.created2017-11-09T13:35:10Z
dc.date.issued2017
dc.identifier.citationTorvik, Fartein Ask Ystrøm, Eivind Gustavson, Kristin Rosenström, Tom Henrik Bramness, Jørgen Gustav Gillespie, N Aggen, S H Kendler, K S Reichborn-Kjennerud, Ted . Diagnostic and genetic overlap of three common mental disorders in structured interviews and health registries. Acta Psychiatrica Scandinavica. 2017, 137(1), 54-64
dc.identifier.urihttp://hdl.handle.net/10852/64936
dc.description.abstractObjective: To investigate whether diagnostic data from structured interviews, primary care and specialist care registries on major depressive disorder (MDD), anxiety disorders (AD) and alcohol use disorder (AUD) identify the same individuals, yield comparable comorbidity estimates and reflect the same genetic influences. Methods: Registry data from primary and specialist care were available for 11 727 twins and diagnostic interview data for 2271 of these. We used logistic regression analyses and biometric modelling to investigate the overlap between the data sources. Results: Most individuals meeting diagnostic criteria at interview were not registered with a corresponding diagnosis. The rates of registration were higher for MDD (36% in primary care and 15% in specialist care) and AD (21% and 18%) than for AUD (3% and 7%). Comorbidity estimated as odds ratios, but not as polychoric correlations, was higher in the registries than in the interviews. Genetic influences on the disorders were highly correlated across data sources (median r = 0.81), bordering unity for MDD and AD. Conclusion: Prevalence and comorbidity estimates differ between registries and population‐based assessment. Nevertheless, diagnoses from health registries reflect the same genetic influences as common mental disorders assessed in the general population, indicating generalizability of aetiological factors across data sources.en_US
dc.languageEN
dc.publisherMunksgaard Forlag
dc.titleDiagnostic and genetic overlap of three common mental disorders in structured interviews and health registriesen_US
dc.typeJournal articleen_US
dc.creator.authorTorvik, Fartein Ask
dc.creator.authorYstrøm, Eivind
dc.creator.authorGustavson, Kristin
dc.creator.authorRosenström, Tom Henrik
dc.creator.authorBramness, Jørgen Gustav
dc.creator.authorGillespie, N
dc.creator.authorAggen, S H
dc.creator.authorKendler, K S
dc.creator.authorReichborn-Kjennerud, Ted
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode2
dc.identifier.cristin1512655
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta Psychiatrica Scandinavica&rft.volume=137&rft.spage=54&rft.date=2017
dc.identifier.jtitleActa Psychiatrica Scandinavica
dc.identifier.volume137
dc.identifier.issue1
dc.identifier.startpage54
dc.identifier.endpage64
dc.identifier.doihttp://dx.doi.org/10.1111/acps.12829
dc.identifier.urnURN:NBN:no-67472
dc.type.documentTidsskriftartikkelen_US
dc.source.issn0001-690X
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/64936/2/overlapp.pdf
dc.type.versionSubmittedVersion


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