Hide metadata

dc.date.accessioned2018-09-11T12:38:01Z
dc.date.available2018-09-11T12:38:01Z
dc.date.created2017-08-03T16:17:25Z
dc.date.issued2017
dc.identifier.citationAzizi, Marzieh Ghourchian, Hedayatoallah Yazdian, Fatemeh Bagheri Fam, Shahla Bekhradnia, Sara Nyström, Bo . Anti-cancerous effect of albumin coated silver nanoparticles on MDA-MB 231 human breast cancer cell line. Scientific Reports. 2017, 7(1), 5178-5196
dc.identifier.urihttp://hdl.handle.net/10852/64624
dc.description.abstractWith the aim of making specific targeting of silver nanoparticles as a drug for tumor cells and developing new anticancer agents, a novel nano-composite was developed. Albumin coated silver nanoparticles (ASNPs) were synthesized, and their anti-cancerous effects were evaluated against MDA-MB 231, a human breast cancer cell line. The synthesized ASNPs were characterized by spectroscopic methods. The morphological changes of the cells were observed by inverted, florescent microscopy and also by DNA ladder pattern on gel electrophoresis; the results revealed that the cell death process occurred through the apoptosis mechanism. It was found that ASNPs with a size of 90 nm and negatively charged with a zeta-potential of about −20 mV could be specifically taken up by tumor cells. The LD50 of ASNPs against MDA-MB 231 (5 μM), was found to be 30 times higher than that for white normal blood cells (152 μM). The characteristics of the synthesized ASNPs included; intact structure of coated albumin, higher cytotoxicity against cancer cells than over normal cells, and cell death based on apoptosis and reduction of gland tumor sizes in mice. This work indicates that ASNPs could be a good candidate for chemotherapeutic drug.en_US
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAnti-cancerous effect of albumin coated silver nanoparticles on MDA-MB 231 human breast cancer cell lineen_US
dc.typeJournal articleen_US
dc.creator.authorAzizi, Marzieh
dc.creator.authorGhourchian, Hedayatoallah
dc.creator.authorYazdian, Fatemeh
dc.creator.authorBagheri Fam, Shahla
dc.creator.authorBekhradnia, Sara
dc.creator.authorNyström, Bo
cristin.unitcode185,15,12,0
cristin.unitnameKjemisk institutt
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1484065
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=7&rft.spage=5178&rft.date=2017
dc.identifier.jtitleScientific Reports
dc.identifier.volume7
dc.identifier.issue1
dc.identifier.startpage5178
dc.identifier.endpage5196
dc.identifier.doihttp://dx.doi.org/10.1038/s41598-017-05461-3
dc.identifier.urnURN:NBN:no-67160
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/64624/1/Publ233.pdf
dc.type.versionPublishedVersion


Files in this item

Appears in the following Collection

Hide metadata

Attribution 4.0 International
This item's license is: Attribution 4.0 International