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dc.date.accessioned2018-09-07T09:56:18Z
dc.date.available2018-09-07T09:56:18Z
dc.date.created2018-08-15T10:13:15Z
dc.date.issued2018
dc.identifier.citationKjøllesdal, Marte Karoline Råberg Smith, George Davey Ariansen, Inger Kristine Holtermann Kinge, Jonas Minet Degerud, Eirik Næss, Øyvind . The association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI. Scientific Reports. 2018, 8(1)
dc.identifier.urihttp://hdl.handle.net/10852/64202
dc.description.abstractThe article aims to describe the association between midlife body mass index (BMI) and cardiovascular disease (CVD)- and all-cause mortality, and to use early adulthood BMI as an instrumental variable for midlife BMI, in order to obtain an estimate less distorted by midlife confounders and reverse causality. Data from Norwegian health surveys (1974–2003) (midlife BMI, smoking, blood pressure, total cholesterol, heart rate), Military Conscription Records, National Tuberculosis Screenings (early adulthood BMI), National Educational Registry and Cause of Death Registry were linked. Participants with data on BMI in early adulthood and midlife were included (n = 148.886). Hazard Ratio (HR) for CVD mortality was higher in men with midlife obesity relative to normal weight (HR = 1.46(95% CI 1.25, 1.70). For all-cause mortality, HR was higher in those with obesity or underweight in midlife relative to normal weight (Men:HR = 1.19(95% CI 1.09, 1.29), HR = 2.49(95% CI 1.81, 3.43) Women:HR = 1.33(95% CI 1.13, 1.56), HR = 1.61(95% CI 1.22, 2.13)). In instrumental variable analyses, increased BMI became more strongly associated with CVD and all-cause mortality, and the increased risk of all-cause mortality among the underweight attenuated.en_US
dc.languageEN
dc.language.isoenen_US
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMIen_US
dc.title.alternativeENEngelskEnglishThe association between BMI and mortality using early adulthood BMI as an instrumental variable for midlife BMI
dc.typeJournal articleen_US
dc.creator.authorKjøllesdal, Marte Karoline Råberg
dc.creator.authorSmith, George Davey
dc.creator.authorAriansen, Inger Kristine Holtermann
dc.creator.authorKinge, Jonas Minet
dc.creator.authorDegerud, Eirik
dc.creator.authorNæss, Øyvind
cristin.unitcode185,52,14,0
cristin.unitnameAvdeling for samfunnsmedisin og global helse
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1602115
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=8&rft.spage=&rft.date=2018
dc.identifier.jtitleScientific Reports
dc.identifier.volume8
dc.identifier.issue1
dc.identifier.pagecount9
dc.identifier.doihttp://dx.doi.org/10.1038/s41598-018-29089-z
dc.identifier.urnURN:NBN:no-66738
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/64202/2/Kjollesdal_2018_The.pdf
dc.type.versionPublishedVersion
cristin.articleid11499


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