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dc.date.accessioned2018-08-31T13:14:38Z
dc.date.available2018-10-03T22:31:12Z
dc.date.created2017-12-17T14:16:12Z
dc.date.issued2017
dc.identifier.citationKatus, Hugo A. Ziegler, André Ekinci, Okan Giannitsis, Evangelos Stough, Wendy Gattis Achenbach, Stephan Blankenberg, Stefan Brueckmann, Martina Collinson, Paul Comanicìu, Dorin Crea, Filippo Dinh, Wilfried Ducrocq, Grégory Flachskampf, Frank A. Fox, Keith A.A. Friedrich, Matthias G. Hebert, Kathy A. Himmelmann, Anders Hlatky, Mark Lautsch, Dominik Lindahl, Bertil Lindholm, Daniel Mills, Nicholas L. Minotti, Giorgio Möckel, Martin Omland, Torbjørn Semjonow, Véronique . Early diagnosis of acute coronary syndrome. European Heart Journal. 2017, 38(41), 3049-3055
dc.identifier.urihttp://hdl.handle.net/10852/64037
dc.description.abstractThe diagnostic evaluation of acute chest pain has been augmented in recent years by advances in the sensitivity and precision of cardiac troponin assays, new biomarkers, improvements in imaging modalities, and release of new clinical decision algorithms. This progress has enabled physicians to diagnose or rule-out acute myocardial infarction earlier after the initial patient presentation, usually in emergency department settings, which may facilitate prompt initiation of evidence-based treatments, investigation of alternative diagnoses for chest pain, or discharge, and permit better utilization of healthcare resources. A non-trivial proportion of patients fall in an indeterminate category according to rule-out algorithms, and minimal evidence-based guidance exists for the optimal evaluation, monitoring, and treatment of these patients. The Cardiovascular Round Table of the ESC proposes approaches for the optimal application of early strategies in clinical practice to improve patient care following the review of recent advances in the early diagnosis of acute coronary syndrome. The following specific ‘indeterminate’ patient categories were considered: (i) patients with symptoms and high-sensitivity cardiac troponin <99th percentile; (ii) patients with symptoms and high-sensitivity troponin <99th percentile but above the limit of detection; (iii) patients with symptoms and high-sensitivity troponin >99th percentile but without dynamic change; and (iv) patients with symptoms and high-sensitivity troponin >99th percentile and dynamic change but without coronary plaque rupture/erosion/dissection. Definitive evidence is currently lacking to manage these patients whose early diagnosis is ‘indeterminate’ and these areas of uncertainty should be assigned a high priority for research.en_US
dc.languageEN
dc.publisherOxford University Press
dc.titleEarly diagnosis of acute coronary syndromeen_US
dc.typeJournal articleen_US
dc.creator.authorKatus, Hugo A.
dc.creator.authorZiegler, André
dc.creator.authorEkinci, Okan
dc.creator.authorGiannitsis, Evangelos
dc.creator.authorStough, Wendy Gattis
dc.creator.authorAchenbach, Stephan
dc.creator.authorBlankenberg, Stefan
dc.creator.authorBrueckmann, Martina
dc.creator.authorCollinson, Paul
dc.creator.authorComanicìu, Dorin
dc.creator.authorCrea, Filippo
dc.creator.authorDinh, Wilfried
dc.creator.authorDucrocq, Grégory
dc.creator.authorFlachskampf, Frank A.
dc.creator.authorFox, Keith A.A.
dc.creator.authorFriedrich, Matthias G.
dc.creator.authorHebert, Kathy A.
dc.creator.authorHimmelmann, Anders
dc.creator.authorHlatky, Mark
dc.creator.authorLautsch, Dominik
dc.creator.authorLindahl, Bertil
dc.creator.authorLindholm, Daniel
dc.creator.authorMills, Nicholas L.
dc.creator.authorMinotti, Giorgio
dc.creator.authorMöckel, Martin
dc.creator.authorOmland, Torbjørn
dc.creator.authorSemjonow, Véronique
cristin.unitcode185,0,0,0
cristin.unitnameUniversitetet i Oslo
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1528504
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Heart Journal&rft.volume=38&rft.spage=3049&rft.date=2017
dc.identifier.jtitleEuropean Heart Journal
dc.identifier.volume38
dc.identifier.issue41
dc.identifier.startpage3049
dc.identifier.endpage3055
dc.identifier.doihttp://dx.doi.org/10.1093/eurheartj/ehx492
dc.identifier.urnURN:NBN:no-66574
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0195-668X
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/64037/2/acs%2Bearly%2Bdiagnosis%2B_manuscript%2Brevision_final.pdf
dc.type.versionAcceptedVersion


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