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dc.date.accessioned2018-08-25T11:48:51Z
dc.date.available2019-05-01T22:46:32Z
dc.date.created2018-01-03T12:42:13Z
dc.date.issued2017
dc.identifier.citationSmistad, Gro Nyström, Bo Zhu, Kaizheng Grønvold, Marthe Karoline Røv-Johnsen, Anne Hiorth, Marianne . Liposomes coated with hydrophobically modified hydroxyethyl cellulose: Influence of hydrophobic chain length and degree of modification. Colloids and Surfaces B: Biointerfaces. 2017, 156, 79-86
dc.identifier.urihttp://hdl.handle.net/10852/63763
dc.description.abstractNanoparticulate systems with an uncharged hydrophilic surface may have a great potential in mucosal drug delivery. In the present study liposomes were coated with hydrophobically modified hydroxyethyl cellulose (HM-HEC) to create a sterically stabilized liposomal system with an uncharged surface. The aim was to clarify the influence of the amount of hydrophobic modification of HEC and the length of the hydrophobic moiety, on the stability of the system and on the release properties. HM-HEC with different degrees of hydrophobic modification (1 and 2 mol%) and hydrophobic groups with different chain lengths (C8, C12, C16) were included in the study, as well as fluid phase and gel phase liposomes. Both types of liposomes were successfully coated with HM-HEC containing 1 mol% of hydrophobic groups, while 2 mol% did not work for the intended pharmaceutical applications. The polymer coated gel phase liposomes were stable (size, zeta potential, leakage) for 24 weeks at 4 °C, with no differences between the C8 and C16 HM-HEC coating. For the fluid phase liposomes a size increase was observed after 24 weeks at 4 °C for all formulations; the C8 HM-HEC coated liposomes increased the most. No differences in the leakage during storage at 4 °C or in the release at 35 °C were observed between the fluid phase formulations. To conclude; HM-HEC with a shorter hydrophobic chain length resulted in a less stable product for the fluid phase liposomes, while no influence of the chain length was observed for the gel phase liposomes (1 mol% HM).en_US
dc.languageEN
dc.publisherElsevier Science
dc.titleLiposomes coated with hydrophobically modified hydroxyethyl cellulose: Influence of hydrophobic chain length and degree of modificationen_US
dc.typeJournal articleen_US
dc.creator.authorSmistad, Gro
dc.creator.authorNyström, Bo
dc.creator.authorZhu, Kaizheng
dc.creator.authorGrønvold, Marthe Karoline
dc.creator.authorRøv-Johnsen, Anne
dc.creator.authorHiorth, Marianne
cristin.unitcode185,15,23,10
cristin.unitnameFarmasi
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1
dc.identifier.cristin1534747
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Colloids and Surfaces B: Biointerfaces&rft.volume=156&rft.spage=79&rft.date=2017
dc.identifier.jtitleColloids and Surfaces B: Biointerfaces
dc.identifier.volume156
dc.identifier.startpage79
dc.identifier.endpage86
dc.identifier.doihttp://dx.doi.org/10.1016/j.colsurfb.2017.04.061
dc.identifier.urnURN:NBN:no-66311
dc.type.documentTidsskriftartikkelen_US
dc.source.issn0927-7765
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/63763/2/Innsendt%2BManuscript%2B%2Bf%25C3%25B8rste%2Bgang%2B%2528til%2BCristin%2529.pdf
dc.type.versionSubmittedVersion


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