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dc.date.accessioned2018-08-25T11:30:54Z
dc.date.available2018-11-27T23:31:16Z
dc.date.created2018-01-31T14:32:18Z
dc.date.issued2017
dc.identifier.citationBjerknes, Kathrin Helmizadeh, Zahra Brustugun, Jørgen Smistad, Gro . Physical stability of moisture-sensitive tablets stored in a canister or as unit-dose. Journal of Pharmacy Practice and Research. 2017, 47(6), 442-448
dc.identifier.urihttp://hdl.handle.net/10852/63762
dc.description.abstractBackground: Knowledge about the long-term stability of tablets outside the original container, e.g. as unit-doses, is limited. This leaves the pharmacist with the dilemma of seeking improved patient safety by use of unit-doses on one side, versus the lack of knowledge about the stability of the repackaged drug on the other. Aim: To screen the physical stability of moisture-sensitive repackaged tablets to identify those with the need for further chemical stability testing. Method: The physical stability of commercially available tablets (16 products) was investigated after 6 months of storage at ambient conditions in canisters for unit-dose production and after 3 months of storage as unit-doses in a climate chamber at 25°C/60% relative humidity (RH). Changes in appearance, colour and mass were investigated in addition to changes in disintegration time, friability and resistance to crushing. Results: The appearance and results of the physical tests for all products were acceptable and within the requirements of the European Pharmacopoeia, except for sodium valproate enteric-coated tablets (Orfiril). These tablets were significantly altered after 3 months of storage as unit-doses at 25°C/60% RH. However, when stored at ambient conditions the tablets complied with the tests. Conclusions: The current study was a screening study limited to the investigation of the physical stability of a selection of moisture-sensitive repackaged tablets. However, although the physical stability is acceptable, the chemical stability and dissolution rate may be altered. The physical tests outlined are simple but could be suitable for selecting candidates for further chemical stability testing. © 2017 The Society of Hospital Pharmacists of Australiaen_US
dc.languageEN
dc.titlePhysical stability of moisture-sensitive tablets stored in a canister or as unit-doseen_US
dc.typeJournal articleen_US
dc.creator.authorBjerknes, Kathrin
dc.creator.authorHelmizadeh, Zahra
dc.creator.authorBrustugun, Jørgen
dc.creator.authorSmistad, Gro
cristin.unitcode185,15,23,10
cristin.unitnameFarmasi
cristin.ispublishedtrue
cristin.fulltextpostprint
dc.identifier.cristin1558886
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Pharmacy Practice and Research&rft.volume=47&rft.spage=442&rft.date=2017
dc.identifier.jtitleJournal of Pharmacy Practice and Research
dc.identifier.volume47
dc.identifier.issue6
dc.identifier.startpage442
dc.identifier.endpage448
dc.identifier.urnURN:NBN:no-66312
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2055-2335
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/63762/1/Manuskript%2Btil%2BJ%2BPharm%2BPract%2BRes.pdf
dc.type.versionAcceptedVersion


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