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dc.date.accessioned2018-08-24T11:57:02Z
dc.date.available2018-08-24T11:57:02Z
dc.date.created2018-02-28T14:56:34Z
dc.date.issued2018
dc.identifier.citationZuber, Verena Jönsson, Erik Gunnar Frei, Oleksandr Witoelar, Aree Thompson, V K Schork, Andrew J Bettella, Francesco Wang, Yunpeng Djurovic, Srdjan Smeland, Olav Bjerkehagen Dieset, Ingrid Fanous, Ayman H. Desikan, Rahul S Küry, Sébastien Bezieau, Stephane Dale, Anders M Mills, Ian Geoffrey Andreassen, Ole Andreas . Identification of shared genetic variants between schizophrenia and lung cancer. Scientific Reports. 2018, 8(1), 674
dc.identifier.urihttp://hdl.handle.net/10852/63703
dc.description.abstractEpidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there is a shared genetic architecture between schizophrenia and cancer, with the aim to identify specific overlapping genetic loci. First, we performed genome-wide enrichment analysis and second, we analyzed specific loci jointly associated with schizophrenia and cancer by the conjunction false discovery rate. We analyzed the largest genome-wide association studies of schizophrenia and lung, breast, prostate, ovary, and colon-rectum cancer including more than 220,000 subjects, and included genetic association with smoking behavior. Polygenic enrichment of associations with lung cancer was observed in schizophrenia, and weak enrichment for the remaining cancer sites. After excluding the major histocompatibility complex region, we identified three independent loci jointly associated with schizophrenia and lung cancer. The strongest association included nicotinic acetylcholine receptors and is an established pleiotropic locus shared between lung cancer and smoking. The two other loci were independent of genetic association with smoking. Functional analysis identified downstream pleiotropic effects on epigenetics and gene-expression in lung and brain tissue. These findings suggest that genetic factors may explain partly the observed epidemiological association of lung cancer and schizophrenia.en_US
dc.languageEN
dc.language.isoenen_US
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleIdentification of shared genetic variants between schizophrenia and lung canceren_US
dc.typeJournal articleen_US
dc.creator.authorZuber, Verena
dc.creator.authorJönsson, Erik Gunnar
dc.creator.authorFrei, Oleksandr
dc.creator.authorWitoelar, Aree
dc.creator.authorThompson, V K
dc.creator.authorSchork, Andrew J
dc.creator.authorBettella, Francesco
dc.creator.authorWang, Yunpeng
dc.creator.authorDjurovic, Srdjan
dc.creator.authorSmeland, Olav Bjerkehagen
dc.creator.authorDieset, Ingrid
dc.creator.authorFanous, Ayman H.
dc.creator.authorDesikan, Rahul S
dc.creator.authorKüry, Sébastien
dc.creator.authorBezieau, Stephane
dc.creator.authorDale, Anders M
dc.creator.authorMills, Ian Geoffrey
dc.creator.authorAndreassen, Ole Andreas
cristin.unitcode185,53,10,11
cristin.unitnameSenter for psykoseforskning
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1569512
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=8&rft.spage=674&rft.date=2018
dc.identifier.jtitleScientific Reports
dc.identifier.volume8
dc.identifier.doihttp://dx.doi.org/10.1038/s41598-017-16481-4
dc.identifier.urnURN:NBN:no-66250
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/63703/1/s41598-017-16481-4.pdf
dc.type.versionPublishedVersion
cristin.articleid674


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