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dc.date.accessioned2018-08-24T07:42:02Z
dc.date.available2018-08-24T07:42:02Z
dc.date.created2017-06-07T10:25:53Z
dc.date.issued2017
dc.identifier.citationByrkjeland, Rune Unhammer Njerve, Ida Arnesen, Harald Seljeflot, Ingebjørg Solheim, Svein . Reduced endothelial activation after exercise is associated with improved HbA1c in patients with type 2 diabetes and coronary artery disease. Diabetes & vascular disease research. 2017, 14(2), 94-103
dc.identifier.urihttp://hdl.handle.net/10852/63687
dc.description.abstractObjective: We have previously reported insignificant changes in HbA1c after exercise in patients with both type 2 diabetes and coronary artery disease. In this study, we investigated the effect of exercise on endothelial function and possible associations between changes in endothelial function and HbA1c. Methods: Patients with type 2 diabetes and coronary artery disease (n = 137) were randomised to 12 months exercise or standard follow-up. Endothelial function was assessed by circulating biomarkers (E-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, von Willebrand factor, tissue plasminogen activator antigen, asymmetric dimethylarginine and L-arginine/asymmetric dimethylarginine ratio). Differences between the randomised groups were analysed by analysis of covariance and correlations by Spearman’s rho or Pearson’s correlation. Results: No effect of exercise on endothelial function was demonstrated. The changes in HbA1c in the exercise group correlated with changes in E-selectin (r = 0.56, p < 0.001), intercellular adhesion molecule-1 (r = 0.27, p = 0.052), vascular cell adhesion molecule-1 (r = 0.32, p = 0.022) and tissue plasminogen activator antigen (r = 0.35, p = 0.011). HbA1c decreased significantly more in patients with versus without a concomitant reduction in E-selectin (p = 0.002), intercellular adhesion molecule-1 (p = 0.011), vascular cell adhesion molecule-1 (p = 0.028) and tissue plasminogen activator antigen (p = 0.009). Conclusion: Exercise did not affect biomarkers of endothelial function in patients with both type 2 diabetes and coronary artery disease. However, changes in biomarkers of endothelial activation correlated with changes in HbA1c, and reduced endothelial activation was associated with improved HbA1c after exercise.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherSAGE Publications Ltd.
dc.titleReduced endothelial activation after exercise is associated with improved HbA1c in patients with type 2 diabetes and coronary artery diseaseen_US
dc.title.alternativeENEngelskEnglishReduced endothelial activation after exercise is associated with improved HbA1c in patients with type 2 diabetes and coronary artery disease
dc.typeJournal articleen_US
dc.creator.authorByrkjeland, Rune
dc.creator.authorUnhammer Njerve, Ida
dc.creator.authorArnesen, Harald
dc.creator.authorSeljeflot, Ingebjørg
dc.creator.authorSolheim, Svein
cristin.unitcode185,53,11,10
cristin.unitnameHjertemedisinsk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1474432
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Diabetes & vascular disease research&rft.volume=14&rft.spage=94&rft.date=2017
dc.identifier.jtitleDiabetes & vascular disease research
dc.identifier.volume14
dc.identifier.issue2
dc.identifier.startpage94
dc.identifier.endpage103
dc.identifier.doihttp://dx.doi.org/10.1177/1479164116679077
dc.identifier.urnURN:NBN:no-66237
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1479-1641
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/63687/2/EXCADI-Endo-Final-Accepted-Dia-Vasc-Dis-2018.pdf
dc.type.versionAcceptedVersion


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