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dc.date.accessioned2018-08-21T07:56:22Z
dc.date.available2018-08-21T07:56:22Z
dc.date.created2018-01-22T10:47:14Z
dc.date.issued2018
dc.identifier.citationGjerde, Priyanthi Borgen Dieset, Ingrid Simonsen, Carmen Elisabeth Hoseth, Eva Zsuzsanna Iversen, Trude Seselie Jahr Lagerberg, Trine Vik Lyngstad, Siv Hege Mørch, Ragni Helene Skrede, Silje Andreassen, Ole Andreas Melle, Ingrid Steen, Vidar Martin . Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis.. Schizophrenia Research. 2017
dc.identifier.urihttp://hdl.handle.net/10852/63277
dc.description.abstractBackground A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. Methods A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. Results An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B = − 0.48, p = 0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B = − 0.54, p = 0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. Conclusion We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.en_US
dc.languageEN
dc.publisherElsevier Science
dc.relation.ispartofHoseth, Eva Zsuzsanna (2018) Aberrant TNF and Notch signaling pathways in schizophrenia and bipolar disorder. Doctoral thesis http://hdl.handle.net/10852/65956
dc.relation.urihttp://hdl.handle.net/10852/65956
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleIncrease in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis.en_US
dc.typeJournal articleen_US
dc.creator.authorGjerde, Priyanthi Borgen
dc.creator.authorDieset, Ingrid
dc.creator.authorSimonsen, Carmen Elisabeth
dc.creator.authorHoseth, Eva Zsuzsanna
dc.creator.authorIversen, Trude Seselie Jahr
dc.creator.authorLagerberg, Trine Vik
dc.creator.authorLyngstad, Siv Hege
dc.creator.authorMørch, Ragni Helene
dc.creator.authorSkrede, Silje
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorMelle, Ingrid
dc.creator.authorSteen, Vidar Martin
cristin.unitcode185,53,10,70
cristin.unitnameNORMENT part UiO
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1548944
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Schizophrenia Research&rft.volume=&rft.spage=&rft.date=2017
dc.identifier.jtitleSchizophrenia Research
dc.identifier.volume197
dc.identifier.startpage253
dc.identifier.endpage260
dc.identifier.doihttp://dx.doi.org/10.1016/j.schres.2017.10.042
dc.identifier.urnURN:NBN:no-65829
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0920-9964
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/63277/4/1-s2.0-S0920996417306709-main.pdf
dc.type.versionPublishedVersion
dc.relation.projectSKGJ/SKGJ-MED-008
dc.relation.projectNFR/223273


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