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dc.date.accessioned2018-08-17T07:55:58Z
dc.date.available2018-08-17T07:55:58Z
dc.date.created2018-06-20T10:35:37Z
dc.date.issued2018
dc.identifier.citationDou, Mengmeng Zhou, Xueliang Fan, Zhirui Ding, Xianfei Li, Lifeng Wang, Shuling Xue, Wenhua Wang, Hui Suo, Zhenhe Deng, Xiaoming . Clinical Significance of Retinoic Acid Receptor Beta Promoter Methylation in Prostate Cancer: A Meta-Analysis. Cellular Physiology and Biochemistry. 2018, 45(6), 2497-2505
dc.identifier.urihttp://hdl.handle.net/10852/63027
dc.description.abstractBackground/Aims: Retinoic acid receptor beta (RAR beta) is a retinoic acid receptor gene that has been shown to play key roles during multiple cancer processes, including cell proliferation, apoptosis, migration and invasion. Numerous studies have found that methylation of the RAR beta promoter contributed to the occurrence and development of malignant tumors. However, the connection between RAR beta promoter methylation and prostate cancer (PCa) remains unknown. This meta-analysis evaluated the clinical significance of RAR beta promoter methylation in PCa. Materials and Methods: We searched all published records relevant to RAR beta and PCa in a series of databases, including PubMed, Embase, Cochrane Library, ISI Web of Science and CNKI. The rates of RAR beta promoter methylation in the PCa and control groups (including benign prostatic hyperplasia and normal prostate tissues) were summarized. In addition, we evaluated the source region of available samples and the methods used to detect methylation. To compare the incidence and variation in RAR beta promoter methylation in PCa and non-PCa tissues, the odds ratio (OR) and 95% confidence interval (CI) were calculated accordingly. All the data were analyzed with the statistical software STATA 12.0. Results: Based on the inclusion and exclusion criteria, 15 articles assessing 1,339 samples were further analyzed. These data showed that the RAR beta promoter methylation rates in PCa tissues were significantly higher than the rates in the non-PCa group (OR=21.65, 95% CI: 9.27-50.57). Subgroup analysis according to the source region of samples showed that heterogeneity in Asia was small (I2=0.0%, P=0.430). Additional subgroup analysis based on the method used to detect RAR beta promoter methylation showed that the heterogeneity detected by MSP (methylation-specific PCR) was relatively small (I2=11.3%, P=0.343). Conclusion: Although studies reported different rates for RAR beta promoter methylation in PCa tissues, the total analysis demonstrated that RAR beta promoter methylation may be correlated with PCa carcinogenesis and that the RAR beta gene is particularly susceptible. Additional studies with sufficient data are essential to further evaluate the clinical features and prognostic utility of RAR beta promoter methylation in PCa.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherKarger
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleClinical Significance of Retinoic Acid Receptor Beta Promoter Methylation in Prostate Cancer: A Meta-Analysisen_US
dc.title.alternativeENEngelskEnglishClinical Significance of Retinoic Acid Receptor Beta Promoter Methylation in Prostate Cancer: A Meta-Analysis
dc.typeJournal articleen_US
dc.creator.authorDou, Mengmeng
dc.creator.authorZhou, Xueliang
dc.creator.authorFan, Zhirui
dc.creator.authorDing, Xianfei
dc.creator.authorLi, Lifeng
dc.creator.authorWang, Shuling
dc.creator.authorXue, Wenhua
dc.creator.authorWang, Hui
dc.creator.authorSuo, Zhenhe
dc.creator.authorDeng, Xiaoming
cristin.unitcode185,53,18,13
cristin.unitnameAvdeling for patologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1592547
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cellular Physiology and Biochemistry&rft.volume=45&rft.spage=2497&rft.date=2018
dc.identifier.jtitleCellular Physiology and Biochemistry
dc.identifier.volume45
dc.identifier.issue6
dc.identifier.startpage2497
dc.identifier.endpage2505
dc.identifier.doihttp://dx.doi.org/10.1159/000488268
dc.identifier.urnURN:NBN:no-65591
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1015-8987
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/63027/1/DouMengmeng%2Band%2BSuo_Cristin-post%2B1592547.pdf
dc.type.versionPublishedVersion


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Attribution-NonCommercial-NoDerivatives 4.0 International
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