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dc.date.accessioned2018-08-15T12:29:39Z
dc.date.available2018-11-23T23:31:54Z
dc.date.created2018-02-21T10:51:07Z
dc.date.issued2018
dc.identifier.citationThorsen, Steffen U. Mårild, Karl Staffan Olsen, Sjurdur Frodi Holst, Klaus Tapia, German Granström, Charlotta Halldorsson, Thorhallur Ingi Cohen, Arieh S. Haugen, Margaretha Lundqvist, Marika Skrivarhaug, Torild Njølstad, Pål Rasmus Joner, Geir Magnus, Per Størdal, Ketil Svensson, Jannet Stene, Lars Christian Mørch . Maternal and Neonatal Vitamin D Status are not associated with Risk of Childhood Type 1 Diabetes: a Scandinavian Case-Cohort Study. American Journal of Epidemiology. 2017
dc.identifier.urihttp://hdl.handle.net/10852/62971
dc.description.abstractStudies on vitamin D status during pregnancy and risk of type 1 diabetes mellitus (T1D) lack consistency and are limited by small sample sizes or single measures of 25-hydroxyvitamin D (25(OH)D). We investigated whether average maternal 25(OH)D plasma concentrations during pregnancy are associated with risk of childhood T1D. In a case-cohort design, we identified 459 children with T1D and a random sample (n = 1,561) from the Danish National Birth Cohort (n = 97,127) and Norwegian Mother and Child Cohort Study (n = 113,053). Participants were born between 1996 and 2009. The primary exposure was the estimated average 25(OH)D concentration, based on serial samples from the first trimester until delivery and on umbilical cord plasma. We estimated hazard ratios using weighted Cox regression adjusting for multiple confounders. The adjusted hazard ratio for T1D per 10-nmol/L increase in the estimated average 25(OH)D concentration was 1.00 (95% confidence interval: 0.90, 1.10). Results were consistent in both cohorts, in multiple sensitivity analyses, and when we analyzed mid-pregnancy or cord blood separately. In conclusion, our large study demonstrated that normal variation in maternal or neonatal 25(OH)D is unlikely to have a clinically important effect on risk of childhood T1D. This is a pre-copyedited, author-produced version of an article accepted for publication following peer review.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherOxford
dc.titleLack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Studyen_US
dc.typeJournal articleen_US
dc.creator.authorThorsen, Steffen U.
dc.creator.authorMårild, Karl Staffan
dc.creator.authorOlsen, Sjurdur Frodi
dc.creator.authorHolst, Klaus
dc.creator.authorTapia, German
dc.creator.authorGranström, Charlotta
dc.creator.authorHalldorsson, Thorhallur Ingi
dc.creator.authorCohen, Arieh S.
dc.creator.authorHaugen, Margaretha
dc.creator.authorLundqvist, Marika
dc.creator.authorSkrivarhaug, Torild
dc.creator.authorNjølstad, Pål Rasmus
dc.creator.authorJoner, Geir
dc.creator.authorMagnus, Per
dc.creator.authorStørdal, Ketil
dc.creator.authorSvensson, Jannet
dc.creator.authorStene, Lars Christian Mørch
cristin.unitcode185,53,46,10
cristin.unitnamePediatri
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1567318
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American Journal of Epidemiology&rft.volume=&rft.spage=&rft.date=2017
dc.identifier.jtitleAmerican Journal of Epidemiology
dc.identifier.volume187
dc.identifier.issue6
dc.identifier.startpage1174
dc.identifier.endpage1181
dc.identifier.pagecount27
dc.identifier.doihttp://dx.doi.org/10.1093/aje/kwx361
dc.identifier.urnURN:NBN:no-65536
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0002-9262
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/62971/1/Thorsen_et_al.pdf
dc.type.versionAcceptedVersion
dc.relation.projectNFR/151918


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