dc.date.accessioned | 2018-08-15T12:29:39Z | |
dc.date.available | 2018-11-23T23:31:54Z | |
dc.date.created | 2018-02-21T10:51:07Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Thorsen, Steffen U. Mårild, Karl Staffan Olsen, Sjurdur Frodi Holst, Klaus Tapia, German Granström, Charlotta Halldorsson, Thorhallur Ingi Cohen, Arieh S. Haugen, Margaretha Lundqvist, Marika Skrivarhaug, Torild Njølstad, Pål Rasmus Joner, Geir Magnus, Per Størdal, Ketil Svensson, Jannet Stene, Lars Christian Mørch . Maternal and Neonatal Vitamin D Status are not associated with Risk of Childhood Type 1 Diabetes: a Scandinavian Case-Cohort Study. American Journal of Epidemiology. 2017 | |
dc.identifier.uri | http://hdl.handle.net/10852/62971 | |
dc.description.abstract | Studies on vitamin D status during pregnancy and risk of type 1 diabetes mellitus (T1D) lack consistency and are limited by small sample sizes or single measures of 25-hydroxyvitamin D (25(OH)D). We investigated whether average maternal 25(OH)D plasma concentrations during pregnancy are associated with risk of childhood T1D. In a case-cohort design, we identified 459 children with T1D and a random sample (n = 1,561) from the Danish National Birth Cohort (n = 97,127) and Norwegian Mother and Child Cohort Study (n = 113,053). Participants were born between 1996 and 2009. The primary exposure was the estimated average 25(OH)D concentration, based on serial samples from the first trimester until delivery and on umbilical cord plasma. We estimated hazard ratios using weighted Cox regression adjusting for multiple confounders. The adjusted hazard ratio for T1D per 10-nmol/L increase in the estimated average 25(OH)D concentration was 1.00 (95% confidence interval: 0.90, 1.10). Results were consistent in both cohorts, in multiple sensitivity analyses, and when we analyzed mid-pregnancy or cord blood separately. In conclusion, our large study demonstrated that normal variation in maternal or neonatal 25(OH)D is unlikely to have a clinically important effect on risk of childhood T1D.
This is a pre-copyedited, author-produced version of an article accepted for publication following peer review. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | Oxford | |
dc.title | Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Thorsen, Steffen U. | |
dc.creator.author | Mårild, Karl Staffan | |
dc.creator.author | Olsen, Sjurdur Frodi | |
dc.creator.author | Holst, Klaus | |
dc.creator.author | Tapia, German | |
dc.creator.author | Granström, Charlotta | |
dc.creator.author | Halldorsson, Thorhallur Ingi | |
dc.creator.author | Cohen, Arieh S. | |
dc.creator.author | Haugen, Margaretha | |
dc.creator.author | Lundqvist, Marika | |
dc.creator.author | Skrivarhaug, Torild | |
dc.creator.author | Njølstad, Pål Rasmus | |
dc.creator.author | Joner, Geir | |
dc.creator.author | Magnus, Per | |
dc.creator.author | Størdal, Ketil | |
dc.creator.author | Svensson, Jannet | |
dc.creator.author | Stene, Lars Christian Mørch | |
cristin.unitcode | 185,53,46,10 | |
cristin.unitname | Pediatri | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1567318 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American Journal of Epidemiology&rft.volume=&rft.spage=&rft.date=2017 | |
dc.identifier.jtitle | American Journal of Epidemiology | |
dc.identifier.volume | 187 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 1174 | |
dc.identifier.endpage | 1181 | |
dc.identifier.pagecount | 27 | |
dc.identifier.doi | http://dx.doi.org/10.1093/aje/kwx361 | |
dc.identifier.urn | URN:NBN:no-65536 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0002-9262 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/62971/1/Thorsen_et_al.pdf | |
dc.type.version | AcceptedVersion | |
dc.relation.project | NFR/151918 | |