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dc.date.accessioned2018-08-09T13:24:39Z
dc.date.available2018-08-09T13:24:39Z
dc.date.created2018-07-04T15:05:35Z
dc.date.issued2018
dc.identifier.citationLeo, Jack Christopher Linke, Dirk . A unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition. AIMS Microbiology. 2018, 4(3), 455-468
dc.identifier.urihttp://hdl.handle.net/10852/62837
dc.description.abstractTransmembrane proteins in the outer membrane of Gram-negative bacteria are almost exclusively β-barrels. They are inserted into the outer membrane by a conserved and essential protein complex called the BAM (for β-barrel assembly machinery). In this commentary, we summarize current research into the mechanism of this protein complex and how it relates to type V secretion. Type V secretion systems are autotransporters that all contain a β-barrel transmembrane domain inserted by BAM. In type Vc systems, this domain is a homotrimer. We argue that none of the current models are sufficient to explain BAM function particularly regarding type Vc secretion. We also find that current models based on the well-studied model system Escherichia coli mostly ignore the pronounced differences in BAM composition between different bacterial species. We propose a more holistic view on how all OMPs, including autotransporters, are incorporated into the lipid bilayer.en_US
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA unified model for BAM function that takes into account type Vc secretion and species differences in BAM compositionen_US
dc.title.alternativeENEngelskEnglishA unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition
dc.typeJournal articleen_US
dc.creator.authorLeo, Jack Christopher
dc.creator.authorLinke, Dirk
cristin.unitcode185,15,29,60
cristin.unitnameSeksjon for genetikk og evolusjonsbiologi
cristin.ispublishedtrue
cristin.fulltextoriginal
dc.identifier.cristin1595689
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIMS Microbiology&rft.volume=4&rft.spage=455&rft.date=2018
dc.identifier.jtitleAIMS Microbiology
dc.identifier.volume4
dc.identifier.issue3
dc.identifier.startpage455
dc.identifier.endpage468
dc.identifier.doihttp://dx.doi.org/10.3934/microbiol.2018.3.455
dc.identifier.urnURN:NBN:no-65405
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2471-1888
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/62837/2/microbiol-04-03-455.pdf
dc.type.versionPublishedVersion


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