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dc.date.accessioned2018-08-09T09:54:13Z
dc.date.available2018-10-25T22:31:10Z
dc.date.created2017-12-15T13:11:24Z
dc.date.issued2017
dc.identifier.citationHovland, Anders Nestvold, Torunn Kristin Bohov, Pavol Trøseid, Marius Aukrust, Pål Berge, Rolf Kristian Nielsen, Erik Waage Retterstøl, Kjetil Lappegård, Knut Tore . Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals. Scandinavian Journal of Clinical and Laboratory Investigation. 2017, 77(8), 628-633
dc.identifier.urihttp://hdl.handle.net/10852/62834
dc.description.abstractBackground: Obesity is a global pandemic leading to increased mortality and increased risk of cardiovascular disease. Bariatric surgery is an established treatment of obesity leading to weight loss and reduction of mortality. To further elucidate how bariatric surgery improves metabolic control, we explored the fatty acid (FA) profiles in morbidly obese subjects treated with lifestyle intervention and subsequent bariatric surgery. Methods: The intervention group consisted of 34 morbidly obese patients scheduled for bariatric surgery and the control group of 17 non-obese patients scheduled for elective laparoscopic procedures. The intervention group had to undergo lifestyle changes preoperatively. Fasting blood samples were drawn at admission, after lifestyle intervention and 1 year after bariatric surgery. Results: At admission, the morbidly obese patients had significantly higher levels of monounsaturated FAs (MUFAs) and lower levels of n-6 polyunsaturated FAs (PUFAs) and n-3 PUFAs than healthy controls (all p-values <.05). In the intervention group, there was a significantly lower level of total FAs after lifestyle intervention, and from admission to 1 year after surgical intervention (both, p < .05), primarily reflecting a lower proportion of saturated FAs (SFAs). Following bariatric surgery, but not after lifestyle changes, there was an increase in the proportion of n-3 PUFA (p < .05) reaching levels not significantly different from healthy controls. Conclusions: Our findings suggest that a reduced proportion of the proposed anti-atherogenic n-3 PUFAs characterizes morbidly obese individuals, and that this FA profile is reversed by bariatric surgery, but not by lifestyle intervention. The final version of this research has been published in Scandinavian Journal of Clinical and Laboratory Investigation. © 2017 Taylor & Francisen_US
dc.languageEN
dc.titleBariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individualsen_US
dc.typeJournal articleen_US
dc.creator.authorHovland, Anders
dc.creator.authorNestvold, Torunn Kristin
dc.creator.authorBohov, Pavol
dc.creator.authorTrøseid, Marius
dc.creator.authorAukrust, Pål
dc.creator.authorBerge, Rolf Kristian
dc.creator.authorNielsen, Erik Waage
dc.creator.authorRetterstøl, Kjetil
dc.creator.authorLappegård, Knut Tore
cristin.unitcode185,53,48,0
cristin.unitnameKlinikk for kirurgi, inflammasjonsmedisin og transplantasjon
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1528033
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scandinavian Journal of Clinical and Laboratory Investigation&rft.volume=77&rft.spage=628&rft.date=2017
dc.identifier.jtitleScandinavian Journal of Clinical and Laboratory Investigation
dc.identifier.volume77
dc.identifier.issue8
dc.identifier.startpage628
dc.identifier.endpage633
dc.identifier.doihttp://dx.doi.org/10.1080/00365513.2017.1393691
dc.identifier.urnURN:NBN:no-65409
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0036-5513
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/62834/1/SCLI-2017-0072_R1_final.pdf
dc.type.versionAcceptedVersion


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