This thesis addresses the topic of how an information system can be used in another domain than that of its origin. Previous research has emphasized how some software packages are designed to work across different organizations and configurations, gathering a collection of features along the way that aim to meet a wide range of functional requirements. Yet, limited research explores how such a generic information system can be adapted to meet the functional requirements of another domain. DHIS2 is an information system that is used in numerous developing countries, primarily in the health domain. Driven by economical and resource-oriented reasons, the system is sometimes seen to cover functional requirements from the domain of logistics. Originally developed as a health management information system, the flexible properties of the system are exploited in unanticipated ways, allowing the country to create a logistics management information system by using much of the same infrastructure and knowledge that is already present in the community. Motivated by the apparent potential of such systems, this thesis explores how an information system's generative and flexible features can be used to release the system from the assumptions of the original domain. By a process identified as "reappropriation", three cases are examined in which DHIS2 is used for health logistics. Following a detailed case study on these implementations, I apply the theoretical framework of socio-technical generativity to explain how a successful adaption to the other domain requires a combination of social and technical enablers. First, the information system requires a flexible architecture that enables an appropriate reconfiguration suitable for the new domain, supported by tools and documentation that increases the likelihood of success. Second, the process must be supported by heterogeneous actors that complement each other during the implementation process. The findings are presented in a "model of reappropriation", which is also the main contribution concluding this thesis.