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dc.date.accessioned2018-07-11T13:06:11Z
dc.date.available2018-07-11T13:06:11Z
dc.date.created2015-11-03T13:31:33Z
dc.date.issued2015
dc.identifier.citationFollin-Arbelet, Virginie Misund, Kristine Naderi, Elin Hallan Ugland, Hege Katrin Sundan, Anders Blomhoff, Heidi Kiil . The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM. Scientific Reports. 2015, 5:13001
dc.identifier.urihttp://hdl.handle.net/10852/62231
dc.description.abstractWe have previously demonstrated that activation of the cyclic adenosine monophosphate (cAMP) pathway kills multiple myeloma (MM) cells both in vitro and in vivo. In the present study we have investigated the potential of enhancing the killing of MM cell lines and primary MM cells by combining the cAMP-elevating compound forskolin with the commonly used MM therapeutic drugs melphalan, cyclophosphamide, doxorubicin, bortezomib and dexamethasone. We observed that forskolin potentiated the killing induced by all the tested agents as compared to treatment with the single agents alone. In particular, forskolin had a synergistic effect on the dexamethasone-responsive cell lines H929 and OM-2. By knocking down the proapoptotic BCL-2 family member BIM, we proved this protein to be involved in the synergistic induction of apoptosis by dexamethasone and forskolin. The ability of forskolin to maintain the killing of MM cells even at lower concentrations of the conventional agents suggests that forskolin may be used to diminish treatment-associated side effects. Our findings support a potential role of forskolin in combination with current conventional agents in the treatment of MM.en_US
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIMen_US
dc.typeJournal articleen_US
dc.creator.authorFollin-Arbelet, Virginie
dc.creator.authorMisund, Kristine
dc.creator.authorNaderi, Elin Hallan
dc.creator.authorUgland, Hege Katrin
dc.creator.authorSundan, Anders
dc.creator.authorBlomhoff, Heidi Kiil
cristin.unitcode185,51,12,13
cristin.unitnameCellesyklus- og apoptosegruppen
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1285879
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=5:13001&rft.spage=&rft.date=2015
dc.identifier.jtitleScientific Reports
dc.identifier.volume5:13001
dc.identifier.doihttp://dx.doi.org/10.1038/srep13001
dc.identifier.urnURN:NBN:no-64813
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/62231/1/Follin-Arbelet_2015.pdf
dc.type.versionPublishedVersion
dc.relation.projectKF/2215992
dc.relation.projectSKGJ/SKGJ-MED-007
dc.relation.projectNFR/223255


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