Sammendrag: Introduction: Hyperbaric oxygen therapy (HBOT) has been used for decades to treat hard to heal wounds without convincing evidence. Patients with diabetes have a high risk of developing foot ulcers, which cause is often a combination of peripheral neuropathy and peripheral artery disease. Complications of a non-healing ulcer can be amputations and limb loss. Method: This review looked at the literature to try to answer if HBOT can decrease the number of major amputations in the diabetic population. All randomized control trials that addressed this question were included in the analysis. The number of healed ulcers and minor amputations were also analyzed. Results: A total of 11 randomized control trials were included in the analysis. Three of these were double blinded and had a placebo group. Eight of the trials had major amputation as an endpoint. The definition of major amputation varied among the studies. 27/284 in the HBOT group had a major amputation, 63/283 in the control- or placebo -group. RR= 0.43(0.28-0.65). p=0.0001. No difference in rate of major amputation was noted among the trials which were rated as high-quality studies. 63/285 in the HBOT group had a minor amputation, 71/284 in the control- or placebo -group. 126/289 wounds healed in the HBOT group and 70/287 healed in the control- or placebo -group. RR=1.8 (1.40-2.78). Conclusion: In this review HBOT reduced the number of major amputation and increased the rate of wound healing, but because of heterogeneity in both study quality and results regarding the effects on major amputations this effect estimate is highly uncertain.