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dc.date.accessioned2018-03-19T09:56:16Z
dc.date.available2018-09-18T22:31:22Z
dc.date.created2017-12-18T15:41:15Z
dc.date.issued2017
dc.identifier.citationChajès, Véronique Assi, Nada Biessy, Carine Ferrari, P. Rinaldi, Sabina Slimani, Nadia Lenoir, GM Baglietto, L His, Mathilde Boutron-Ruault, M.C. Trichopoulou, A Lagiou, P. Katsoulis, M Kaaks, R. Kuhn, T. Panico, S. Pala, V Masala, G Bueno-De-Mesquita, Hendrik Bastiaan Peeters, P.H. van Gils, Carla Hjartåker, Anette Olsen, Karina Borgund Barnung, Runa Barricarte, A Redondo-Sánchez, Daniel Menéndez, V Amiano, P. Wennberg, Maria Key, T Khaw, K. T. Merritt, MA Riboli, E Gunter, MJ Romieu, I . A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study. Annals of Oncology. 2017, 28(11), 2836-2842
dc.identifier.urihttp://hdl.handle.net/10852/61101
dc.description.abstractBackground Intakes of specific fatty acids have been postulated to impact breast cancer risk but epidemiological data based on dietary questionnaires remain conflicting. Materials and methods We assessed the association between plasma phospholipid fatty acids and breast cancer risk in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition study. Sixty fatty acids were measured by gas chromatography in pre-diagnostic plasma phospholipids from 2982 incident breast cancer cases matched to 2982 controls. Conditional logistic regression models were used to estimate relative risk of breast cancer by fatty acid level. The false discovery rate (q values) was computed to control for multiple comparisons. Subgroup analyses were carried out by estrogen receptor (ER) and progesterone receptor expression in the tumours. Results A high level of palmitoleic acid [odds ratio (OR) for the highest quartile compared with the lowest OR (Q4–Q1) 1.37; 95% confidence interval (CI), 1.14–1.64; P for trend = 0.0001, q value = 0.004] as well as a high desaturation index (DI16) (16:1n–7/16:0) [OR (Q4–Q1), 1.28; 95% C, 1.07–1.54; P for trend = 0.002, q value = 0.037], as biomarkers of de novo lipogenesis, were significantly associated with increased risk of breast cancer. Levels of industrial trans-fatty acids were positively associated with ER-negative tumours [OR for the highest tertile compared with the lowest (T3–T1)=2.01; 95% CI, 1.03–3.90; P for trend = 0.047], whereas no association was found for ER-positive tumours (P-heterogeneity =0.01). No significant association was found between n-3 polyunsaturated fatty acids and breast cancer risk, overall or by hormonal receptor. Conclusion These findings suggest that increased de novo lipogenesis, acting through increased synthesis of palmitoleic acid, could be a relevant metabolic pathway for breast tumourigenesis. Dietary trans-fatty acids derived from industrial processes may specifically increase ER-negative breast cancer risk. This is a pre-copyedited, author-produced version of an article accepted for publication in Annals of Oncology following peer review. The version of record is available online at: https://doi.org/10.1093/annonc/mdx482en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherKluwer Academic/Plenum Publishers
dc.titleA prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC studyen_US
dc.typeJournal articleen_US
dc.creator.authorChajès, Véronique
dc.creator.authorAssi, Nada
dc.creator.authorBiessy, Carine
dc.creator.authorFerrari, P.
dc.creator.authorRinaldi, Sabina
dc.creator.authorSlimani, Nadia
dc.creator.authorLenoir, GM
dc.creator.authorBaglietto, L
dc.creator.authorHis, Mathilde
dc.creator.authorBoutron-Ruault, M.C.
dc.creator.authorTrichopoulou, A
dc.creator.authorLagiou, P.
dc.creator.authorKatsoulis, M
dc.creator.authorKaaks, R.
dc.creator.authorKuhn, T.
dc.creator.authorPanico, S.
dc.creator.authorPala, V
dc.creator.authorMasala, G
dc.creator.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.creator.authorPeeters, P.H.
dc.creator.authorvan Gils, Carla
dc.creator.authorHjartåker, Anette
dc.creator.authorOlsen, Karina
dc.creator.authorBorgund Barnung, Runa
dc.creator.authorBarricarte, A
dc.creator.authorRedondo-Sánchez, Daniel
dc.creator.authorMenéndez, V
dc.creator.authorAmiano, P.
dc.creator.authorWennberg, Maria
dc.creator.authorKey, T
dc.creator.authorKhaw, K. T.
dc.creator.authorMerritt, MA
dc.creator.authorRiboli, E
dc.creator.authorGunter, MJ
dc.creator.authorRomieu, I
cristin.unitcode185,51,13,30
cristin.unitnameSeksjon for ernæringsepidemiologi
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1529205
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Annals of Oncology&rft.volume=28&rft.spage=2836&rft.date=2017
dc.identifier.jtitleAnnals of Oncology
dc.identifier.volume28
dc.identifier.issue11
dc.identifier.startpage2836
dc.identifier.endpage2842
dc.identifier.doihttp://dx.doi.org/10.1093/annonc/mdx482
dc.identifier.urnURN:NBN:no-63725
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0923-7534
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/61101/1/Plasma%2BPL%2Bfatty%2Bacids%2Band%2Bbreast%2Bcancer%2B-%2Baccepted%2BAnnals%2BOncol_2017_08_02.pdf
dc.type.versionAcceptedVersion


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