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dc.date.accessioned2018-03-12T13:15:41Z
dc.date.available2018-03-12T13:15:41Z
dc.date.created2017-06-08T12:35:17Z
dc.date.issued2017
dc.identifier.citationShetelig, Christian Shanmuganathan, Limalanathan Eritsland, Jan HOFFMANN, PAVEL Seljeflot, Ingebjørg Gran, Jon Michael Aukrust, Pål Ueland, Thor Andersen, Geir Øystein . Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function. PLoS ONE. 2017, 12:e0173034(3), 1-14
dc.identifier.urihttp://hdl.handle.net/10852/60912
dc.description.abstractBackground Elevated levels of osteoprotegerin (OPG) have been associated with adverse outcomes in ST-elevation myocardial infarction (STEMI). However, the role of OPG in myocardial injury and adverse remodeling in STEMI patients remains unclear. The aims of this observational cohort study were to evaluate: 1) the temporal profile of OPG during STEMI, 2) possible associations between OPG measured acutely and after 4 months, with infarct size, adverse left ventricular (LV) remodeling, microvascular obstruction (MVO) and myocardial salvage and 3) the effect of heparin administration on OPG levels. Methods Blood samples were drawn repeatedly from 272 STEMI patients treated with primary percutaneous coronary intervention (PCI). Cardiac magnetic resonance imaging (CMR) was performed in the acute phase and after 4 months. The effect of heparin administration on OPG levels was studied in 20 patients referred to elective coronary angiography. Results OPG levels measured acutely were significantly higher than Day 1 and during follow-up. OPG levels were correlated with age. No association was found between early OPG levels and CMR measurements at 4 months. Patients with >median OPG levels measured at Day 1 had larger final infarct size, lower LV ejection fraction (LVEF) at 4 months and higher frequency of MVO. There were no associations between OPG and change in end-diastolic volume or myocardial salvage. OPG remained associated with infarct size and LVEF after adjustment for relevant covariates, except peak troponin T and CRP. A 77% increase in OPG levels following heparin administration was found in patients undergoing elective coronary angiography. Conclusions OPG was found to be associated with myocardial injury, but not with LV remodeling or myocardial salvage. The use of OPG as a biomarker in STEMI patients seems to be limited by a strong association with age, confounding effect of heparin administration, and little additive value to established biomarkers.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleOsteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular functionen_US
dc.typeJournal articleen_US
dc.creator.authorShetelig, Christian
dc.creator.authorShanmuganathan, Limalanathan
dc.creator.authorEritsland, Jan
dc.creator.authorHOFFMANN, PAVEL
dc.creator.authorSeljeflot, Ingebjørg
dc.creator.authorGran, Jon Michael
dc.creator.authorAukrust, Pål
dc.creator.authorUeland, Thor
dc.creator.authorAndersen, Geir Øystein
cristin.unitcode185,53,11,10
cristin.unitnameHjertemedisinsk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1474729
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=12:e0173034&rft.spage=1&rft.date=2017
dc.identifier.jtitlePLoS ONE
dc.identifier.volume12
dc.identifier.issue3
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0173034
dc.identifier.urnURN:NBN:no-63557
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1932-6203
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/60912/2/PLOSOne%2BShetelig%2BOPG%2B2017.pdf
dc.type.versionPublishedVersion
cristin.articleide0173034


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