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dc.date.accessioned2018-02-22T13:32:18Z
dc.date.created2017-06-29T17:10:25Z
dc.date.issued2017
dc.identifier.citationLagos, Leidy Tandberg, Julia Isabel Becker, María Inés Winther-Larsen, Hanne Cecilie . Immunomodulatory properties of Concholepas concholepas hemocyanin against francisellosis in a zebrafish model. Fish and Shellfish Immunology. 2017, 67, 571-574
dc.identifier.urihttp://hdl.handle.net/10852/60294
dc.description.abstractThe development of vaccines for aquaculture has been an important milestone in providing a continuous and sustainable production. Most of the vaccines currently on the market for aquaculture include oil as adjuvant. Nevertheless, several studies reported an occurrence of side effects after their use in farmed fish. As a result, there is a need for new and improved adjuvants that can stimulate the immune system while causing as few side-effects as possible. Hemocyanins are versatile macromolecules with strong immunogenic and immunomodulatory properties. Due to these characteristics, hemocyanin from Concholepas concholepas (CCH) has been biochemically characterized and evaluated as vaccine adjuvant in mice and humans. Francisellosis is a chronic granulomatous disease, which can result in high mortality depending on the host. The disease is caused by the facultative intracellular Gram-negative bacteria Francisella noatunensis, which remains an unsolved problem for the aquaculture, as no efficient vaccines are available. The aim of the present work was to investigate the immunoregulatory properties of CCH against francisellosis in an experimental zebrafish model. When immunized with CCH, zebrafish were protected from subsequent challenge with a lethal dose of Francisella noatunensis subsp. orientalis. Subsequently the mRNA expression levels of several immune-related genes were studied, including mhcii, il12a, tnfα and ifng1-1. Taken together, the data report the immunoregulatory properties of CCH and its potential use as a vaccine adjuvant for aquaculture.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleImmunomodulatory properties of Concholepas concholepas hemocyanin against francisellosis in a zebrafish modelen_US
dc.typeJournal articleen_US
dc.creator.authorLagos, Leidy
dc.creator.authorTandberg, Julia Isabel
dc.creator.authorBecker, María Inés
dc.creator.authorWinther-Larsen, Hanne Cecilie
cristin.unitcode185,15,23,30
cristin.unitnameFarmasøytisk biovitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1479977
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Fish and Shellfish Immunology&rft.volume=67&rft.spage=571&rft.date=2017
dc.identifier.jtitleFish and Shellfish Immunology
dc.identifier.volume67
dc.identifier.startpage571
dc.identifier.endpage574
dc.identifier.doihttp://dx.doi.org/10.1016/j.fsi.2017.06.046
dc.identifier.urnURN:NBN:no-63006
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1050-4648
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/60294/6/1-s2-0-S1050464817303698.pdf
dc.type.versionPublishedVersion


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