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dc.date.accessioned2018-02-14T18:47:21Z
dc.date.available2018-02-14T18:47:21Z
dc.date.created2007-02-15T14:14:39Z
dc.date.issued2006
dc.identifier.citationThomassen, Gard O. S. Rosok, Oystein Rognes, Torbjørn . Computational prediction of microRNAs encoded in viral and other genomes. Journal of Biomedicine and Biotechnology. 2006
dc.identifier.urihttp://hdl.handle.net/10852/60115
dc.description.abstractWe present an overview of selected computational methods for microRNA prediction. It is especially aimed at viral miRNA detection. As the number of microRNAs increases and the range of genomes encoding miRNAs expands, it seems that these small regulators have a more important role than has been previously thought. Most microRNAs have been detected by cloning and Northern blotting, but experimental methods are biased towards abundant microRNAs as well as being time-consuming. Computational detection methods must therefore be refined to serve as a faster, better, and more affordable method for microRNA detection. We also present data from a small study investigating the problems of computational miRNA prediction. Our findings suggest that the prediction of microRNA precursor candidates is fairly easy, while excluding false positives as well as exact prediction of the mature microRNA is hard. Finally, we discuss possible improvements to computational microRNA detection.en_US
dc.languageEN
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporation
dc.rightsAttribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleComputational prediction of microRNAs encoded in viral and other genomesen_US
dc.typeJournal articleen_US
dc.creator.authorThomassen, Gard O. S.
dc.creator.authorRosok, Oystein
dc.creator.authorRognes, Torbjørn
cristin.unitcode185,15,5,35
cristin.unitnameForskningsgruppen for biomedisinsk informatikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin502363
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Biomedicine and Biotechnology&rft.volume=&rft.spage=&rft.date=2006
dc.identifier.jtitleJournal of Biomedicine and Biotechnology
dc.identifier.volume2006
dc.identifier.pagecount10
dc.identifier.doihttp://dx.doi.org/10.1155/JBB/2006/95270
dc.identifier.urnURN:NBN:no-62783
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1110-7243
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/60115/2/2006%2BThomassen%2Bet%2Bal.pdf
dc.type.versionPublishedVersion
cristin.articleid95270


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