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dc.date.accessioned2018-02-06T16:48:55Z
dc.date.available2018-09-20T22:31:11Z
dc.date.created2017-04-24T15:04:00Z
dc.date.issued2017
dc.identifier.citationMurphy, Ricardo . On the use of one-sided statistical tests in biomedical research. Clinical and Experimental Pharmacology and Physiology. 2017
dc.identifier.urihttp://hdl.handle.net/10852/59912
dc.description.abstractThere is a tendency to automatically use two-sided tests to assess the statistical significance of experimental results. Yet if a theory predicts the direction of an experimental outcome, or if for some practical (eg clinical) reason an outcome in that direction is the only one of interest, then it makes sense to use a one-sided test. The use of a two-sided test in these situations will lead to too many false negatives. Consequently treatment effects that corroborate a theory or that are of practical importance may be missed. This problem becomes particularly acute in the case of borderline results. Following a nonsignificant one-sided test, the possibility of an effect in the direction opposite to that predicted or required can be assessed in an exploratory fashion by computing the odds in favour of such an effect. Anyone is then at liberty to pursue this possibility as they see fit. The question of whether to use a one-sided or two-sided statistical test should always be decided on logical grounds not statistical ones, and suspicions regarding the motives of the investigator(s) should be disregarded. On the other hand, this choice can be avoided altogether by assuming that a treatment always has some effect (however small) and then computing the strength of the evidence in favour of the observed or predicted/required effect (ie 1-P, where P is the one-sided significance level of the test). With this approach one-sided and two-sided tests yield identical results, and so there is effectively only one type of test. The final version of this research has been published in Clinical and Experimental Pharmacology and Physiology. © 2017 Wileyen_US
dc.languageEN
dc.publisherBlackwell Publishing
dc.titleOn the use of one-sided statistical tests in biomedical researchen_US
dc.typeJournal articleen_US
dc.creator.authorMurphy, Ricardo
cristin.unitcode185,51,11,13
cristin.unitnameFysiologi: Hjernesignaler
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1466273
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical and Experimental Pharmacology and Physiology&rft.volume=&rft.spage=&rft.date=2017
dc.identifier.jtitleClinical and Experimental Pharmacology and Physiology
dc.identifier.doihttp://dx.doi.org/10.1111/1440-1681.12754
dc.identifier.urnURN:NBN:no-62574
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0305-1870
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/59912/1/Ricardo%2BMurphy%2B2017%2B-%2BOn%2Bthe%2Buse%2Bof%2Bone-sided%2Bstatistical%2Btests%2Bin%2Bbiomedical%2Bresearch.pdf
dc.type.versionAcceptedVersion


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